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糖组学技术及其在疾病标志物挖掘中的应用 被引量:1

Glycomic technology and its application in disease marker mining
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摘要 蛋白质糖基化修饰的变化与癌症和其他疾病密切相关,也成为挖掘肿瘤等疾病诊疗标志物的有效手段。定量技术的精准是揭示糖组奥秘的关键前提,糖链疾病标志物的筛选和验证离不开对临床大样本的研究,因此糖组学研究和应用技术应简便、快速、高通量、准确和实用。本文对一些常用糖组分析技术特点及其在糖链标志物中的应用研究进行了简要论述,重点阐述了基于基质辅助激光解吸离子化飞行时间质谱的高通量精准糖组定量方法的特点、进展和应用。 Changes in protein glycosylation modification have been found to be closely related to cancer and other diseases.Profiling glycosylation change has become an effective way to explore the diagnosis and treatment markers.The accuracy of quantitative technology is the key to reveal the mystery of glycosylation,and the screening and validation of glycosylation disease markers is dependant on the study of large clinical samples.Therefore,glycomic technology are expected to be simple,rapid,high-throughput,accurate and practical.In this paper,the characteristics of some commonly used glycomic analysis techniques and their applications in glycan markers are briefly discussed,and the characteristics,progress and applications of high-throughput precision glycome quantitative methods based on MALDI MS are emphasized.
作者 任士芳 顾建新 Ren Shifang;Gu Jianxin(NHC Key Laboratory of Glycoconjugates Research,Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China)
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2022年第4期318-322,共5页 Chinese Journal of Laboratory Medicine
关键词 糖组学 质谱分析法 糖链标志物 Glycomics Mass Spectrometry Glycan markers
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