晚期糖基化终末产物的研究现状

Current status on the laboratory determination of advanced glycation end products

晚期糖基化终末产物(AGE)在体内的浓度及蓄积速度与糖代谢性疾病高度相关,因此AGE的临床检测对该类疾病的早期诊断及疾病预后评估具有重要意义。然而由于其结构复杂、糖基化位点多样以及现有检测方法的局限性,尚缺乏可广泛用于临床的检测方法。该文从AGE的结构与分类、临床检测价值等方面,阐述目前各种检测方法的现状,并对各种检测方法的不足及面临的挑战进行了展望。

The concentration and accumulation rate of advanced glycation end products(AGEs)in the body are highly correlated with glycometabolic disorders.Therefore,the clinical detection of AGEs is of great value for the early diagnosis and prognostic evaluation of these diseases.However,due to the complexity of its structure,the diversity of glycosylation sites,and the limitations of existing detection methods,there is still a lack of widely available detection methods in clinical practice.Starting from the structure and classification of AGEs and the value of clinical testing,this article summarizes current status of various laboratory detection methods of AGEs,and the deficiencies and challenges of these testing methods,future directions are further prospected.