摘要
骨关节炎(osteoarthritis,OA)是一种以软骨细胞减少、细胞外基质破坏为特征的慢性骨关节功能紊乱性疾病,已成为老年人致残的主要原因。近年来研究发现,微小RNA(microRNAs,miRNAs)表达异常介导的炎症反应相关信号通路在OA发生发展中发挥着关键调控作用。本文通过总结近年来调控OA发生发展的相关炎症信号通路及miRNAs对这些信号通路的调控机制,进一步明确OA发生发展的分子作用机制,为OA的诊治开拓新的思路和方向。
Osteoarthritis(OA)is a chronic functional disorder of bone and joint characterized by the decrease of chondrocytes and the destruction of extracellular matrix.It has become the main cause of disability in the elderly.In recent years,it has been found that abnormal expression of microRNAs(miRNAs)mediated inflammatory response related signal pathways play a key regulatory role in the occurrence and development of OA.This paper summarizes the relevant inflammatory signal pathways regulating the occurrence and development of OA in recent years and the regulatory mechanism of miRNAs on these signal pathways,further clarify the molecular mechanism of the occurrence and development of OA,and bring new ideas and directions for the diagnosis and treatment of osteoarthritis.
作者
孟祥睿
安方玉
颜春鲁
邓婕
李朝晖
张金龙
郭丹
李嘉进
吕学颖
MENG Xiang-rui;AN Fang-yu;YAN Chun-lu;DENG Jie;LI Zhao-hui;ZHANG Jin-long;GUO Dan;LI Jia-jin;LV Xue-ying(The First College of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China;Teaching Experiment Training Center, Gansu University of Chinese Medicine, Lanzhou 730000, China;College of Integrated Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China;Gansu Key Laboratory of Chronic Diseases for Prevention and Treatment of Traditional Chinese Medicine,Lanzhou 730000, China;Clinical College of Traditional Chinese Medicine, Gansu University ofChinese Medicine, Lanzhou 730000, China)
出处
《中华骨质疏松和骨矿盐疾病杂志》
CSCD
北大核心
2022年第2期196-205,共10页
Chinese Journal Of Osteoporosis And Bone Mineral Research
基金
甘肃省自然科学基金(20JR5RA185,20JR5RA616)
甘肃省高校大学生就业创业能力提升工程项(6-1)
甘肃省高校重大疾病分子医学与中医药防治研究重点实验室开放基金(FZYX17-18-10)
甘肃省中医药管理局科研项目(GZKP-2021-34)
甘肃省“双一流”科研重点项目(GSSYLXM-05)。
关键词
骨关节炎
炎症反应
信号通路
微小RNA
osteoarthritis
inflammatory response
signal pathway
microRNAs
