脊柱结核易感性与相关基因多态性研究进展

Susceptibility of spinal tuberculosis and its related gene polymorphisms

脊柱结核作为最严重的肺外结核形式之一,是导致发展中国家人群脊柱畸形和瘫痪的主要原因之一。其致残率和病死率较高,严重影响人们的生活质量。脊柱结核的发病与性别、年龄、环境、生活习惯以及遗传等多因素相关。基因多态性作为遗传因素在结核病发生、发展中起到重要作用,因此本文就脊柱结核的易感性与相关基因多态性的研究进展进行综述,以期对脊柱结核早期预防和治疗提供参考。

Spinal tuberculosis,as one of the most serious forms of extrapulmonary tuberculosis,is one of the primary causes of spinal deformity and paralysis in developing countries.It immensely affects people's quality of life with high incidences of deformity and disability.The onset of spinal tuberculosis is related to many factors such as gender,age,environment,habits and genetics.As a genetic factor,gene polymorphism plays an important role in the occurrence and development of tuberculosis.Hence,this article reviews the research progress of the susceptibility of spinal tuberculosis and its related gene polymorphisms,in order to provide reference for early prevention and treatment of spinal tuberculosis.