Janus激酶3在临床应用中的研究与进展

Correlation and progress of Janus kinase 3 in clinical application

Janus激酶3(JAK3)属于与膜相关的细胞内非受体酪氨酸蛋白激酶家族中的一个成员,由细胞因子及生长因子发起的信号通过JAK/STAT途径介导。JAK3主要在造血细胞和免疫细胞中表达,参与细胞的增殖、分化、迁移、存活等过程。JAK3在血管细胞、癌细胞等某些非造血细胞中也存在表达。JAK3作为一种平滑肌细胞增殖和血管重塑的新型调节剂,可能与动脉粥样硬化形成密切相关。该文从JAK3的结构、信号通路、生物学功能及临床应用方面进行综述。

Janus kinase 3(JAK3)is a member of the membrane-associated intracellular non-receptor tyrosine protein kinase family.Signals initiated by cytokines and growth factors are mediated through the JAK/STAT pathway.It is mainly expressed in hematopoietic cells and immune cells,and participates in the processes of cell proliferation,differentiation,migration,and survival.JAK3 is also expressed in certain non-hematopoietic cells including vascular cells and cancer cells.Recent studies have found that JAK3,a novel regulator of smooth muscle cell(SMC)proliferation and vascular remodeling,may be closely related to atherosclerosis.This article reviews the structure,signaling pathways,biological functions and clinical applications of human JAK3.