Lefamulin:一种新型人用截短侧耳素类抗菌药物的临床药学研究

Clinical pharmacology of lefamulin-a new pleuromutilin class of antibiotics for human use

Lefamulin是全球首个静脉和口服剂型的人用截短侧耳素类抗菌药物,具有独特的作用机制,与其他临床用抗菌药物不易产生交叉耐药性。对社区获得性肺炎、皮肤软组织感染以及性传播疾病的常见病原体有良好的抗菌活性。本文就lefamulin的作用机制、耐药机制、抗菌活性以及临床使用等方面进行综述。

Lefamulin,the first semisynthetic pleuromutilin antibacterial for oral and intravenous administration in patients,has a unique mechanism against bacteria and does not show cross-resistance with other antimicrobials.In vitro studies have demonstrated that lefamulin has potent activity against a variety of bacteria that cause communityacquired pneumonia,skin and soft tissue infections and sexually transmitted diseases.This article reviews the mechanism,drug resistance,antibacterial activity,and clinical use of lefamulin.