血清肿瘤标志物联合检测在原发性肝癌诊断中的应用价值

Application Value of Combined Detection of Serum Tumor Markers in the Diagnosis of Primary Liver Cancer

目的探讨甲胎蛋白(AFP)、糖类抗原(CA-125、CA-199)及癌胚抗原(CEA)联合检测在原发性肝癌诊断中的应用价值。方法选择2019年1月至2021年1月于医院住院的50例原发性肝癌患者为原发性肝癌组,50例乙型肝炎患者为肝炎组,同时选取同期的50名健康体检者为健康组,检测所有受试者的血清AFP、CA-125、CA-199和CEA水平,比较3组血清肿瘤标志物的水平,以及4种血清肿瘤标志物单独检测及联合检测在原发性肝癌患者中的阳性率。结果3组血清AFP、CA-125、CA-199和CEA水平比较,差异均有统计学意义(P<0.05);原发性肝癌组的血清AFP、CA-125、CA-199和CEA水平均高于乙型肝炎组,差异有统计学意义(P<0.05);原发性肝癌组的血清AFP、CA-125、CA-199和CEA水平均高于健康组,差异有统计学意义(P<0.05)。血清肿瘤标志物AFP、CA-125、CA-199和CEA联合检测在原发性肝癌患者中的阳性率为96.00%(48/50),高于分别单独检测的74.00%(37/50),64.00%(32/50),56.00%(28/50)及46.00%(23/50),差异均有统计学意义(P<0.05)。结论血清标志物AFP、CA-125、CA-199、CEA联合检测对原发性肝癌的诊断效果优于单独检测,可对原发性肝癌的早期诊断提供重要的依据。

Objective The application value of alpha fetoprotein(AFP),carbohydrate antigen(CA-125 and CA-199)and carcinoembryonic antigen(CEA)combined detection in the diagnosis of primary liver cancer was explored.Methods 50 patients with primary liver cancer admitted to the hospital from January 2019 to January 2021 were selected as the primary liver cancer group and 50 patients with hepatitis B were selected as the hepatitis B group.Meanwhile,50 healthy persons received normal physical examination during the same period were selected as the health group.The AFP,CA-125,CA-199 and CEA levels in serum were detected for all subjects.The levels of serum tumor markers in the three groups and the positive rate of the four serum tumor markers in primary liver cancer patients alone and the positive rate of combined detection were compared.Results When the levels of AFP,CA-125,CA-199 and CEA in serum in the three groups were compared,the difference was statistically significant(P<0.05);The levels of AFP,CA-125,CA-199 and CEA in serum in the primary liver cancer group were higher than those in the hepatitis B group,the differences were statistically significant(P<0.05);The levels of AFP,CA-125,CA-199 and CEA in serum in the primary liver cancer group were higher than those in the health group,the differences were statistically significant(P<0.05).The positive rate of combined detection of AFP,CA-125,CA-199 and CEA in primary liver patients was 96.00%(48/50),which was higher than alone detection[AFP for 74.00%(37/50),CA-125 for 64.00%(32/50),CA-199 for 56.00%(28/50)and CEA for 46.00%(23/50)],and the differences were statistically significant(P<0.05).Conclusion Combined detection for serum tumor markers AFP,CA-125,CA-199 and CEA has a better diagnostic effect than alone detection for primary liver cancer,so it can provide important reference for early diagnosis of primary liver cancer.