神经胶质瘤发病机制及免疫治疗研究新进展

Research progress on the pathogenesis and immunotherapy of glioma

神经胶质瘤是中枢神经系统最常见的一种原发性恶性肿瘤,对人们的生活质量和健康造成了严重危害。近年来,关于神经胶质瘤发病机制的研究已取得很大进步;随着免疫学研究的不断深入,免疫治疗也已成为神经胶质瘤研究的又一新的热点。本文对胶质瘤发病机制进行阐述,并按照原理的不同将免疫治疗分为3种类型,即阻断免疫抑制性因素疗法、增强免疫激活性因素疗法和利用免疫手段调节肿瘤发生过程疗法,并展开阐述各类疗法的具体应用与研究进展。最后,列举目前有关神经胶质瘤免疫治疗的各类研究中存在的问题,提出部分可行的解决方案,为相关研究提供更多思路。

Glioma is one of the most common primary malignant tumors in the central nervous system,which has caused serious harm to people’s quality of life and health.In recent years,great advances have been achieved in research concerning the pathogenesis of glioma.With deepened understanding of immunology,immunotherapy has become another new hot spot in the research of glioma.In this paper,we discussed the pathogenesis of glioma.According to the mechanism of action,immunotherapy was divided into three different types:therapies that block immunosuppressive factors,therapies that enhance immune and active factors,and immunological approaches to regulate tumorigenesis.Meanwhile,the specific application and research progress on various types of therapy were introduced.Finally,the current problems in various studies on glioma immunotherapy were listed,while some feasible solutions were proposed to provide more thoughts for related research.