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慢性阻塞性肺疾病患者血清lncRNA IL-6-AS1水平及其与肺功能的相关性分析 被引量:5

Serum lncRNA IL-6-AS1 level and its correlation with pulmonary function in patients with chronic obstructive pulmonary disease
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摘要 目的分析慢阻肺患者血清lncRNA IL-6-AS1水平变化及其与肺功能相关性。方法筛选2020年1月到2021年6月在我院接受治疗的慢阻肺患者132例及同期健康老年体检者70例做对照,对比患者血清lncRNA IL-6-AS1水平和肺功能指标并分析其相关性。实时定量PCR(RT-PCR)检测血清lncRNA IL-6-AS1水平,采用肺功能仪检测呼气峰流速(Peak expiratory flow,PEF)占预计值百分比,第1 s用力呼气容积(Forced expiratory volume1,FEV_(1))占预计值的百分比% pred),第1 s用力呼气容积与用力肺活量(Forced volume vital capacity,FVC)比值。结果与对照组相比,慢阻肺患者lncRNA IL-6-AS1相对表达水平为(1.43±0.13),急性加重期组患者lncRNA IL-6-AS1相对表达水平为(1.73±0.17),表达水平显著上调,而PEF% pred,FEV_(1)%pred和FEV_(1)/FVC显著降低。相关性分析结果表明,lncRNA IL-6-AS1与PEF% pred,FEV_(1)% pred和FEV_(1)/FVC呈负相关。结论老年慢阻肺患者血清lncRNA IL-6-AS1水平呈高表达,与患者肺功能下降有关。lncRNA IL-6-AS1可能是慢性阻塞性疾病临床诊疗很有潜力的分子靶点。 Objective To analyze the changes of serum lncRNA IL-6-AS1 level in patients with chronic obstructive disease(COPD)and its correlation with pulmonary function.Methods A total of 132 COPD patients treated in our hospital from January 2020 to June 2021 and 70 healthy elderly subjects during the same period were screened as controls,and their serum lncRNA IL-6-AS1 levels and pulmonary function parameters were compared and their correlations were analyzed.Serum lncRNAIL-6-AS1 level was measured by real-time quantitative PCR(RT-PCR),and the percentage of peak expiratory flow to predicted value(PEF% pred),the percentage of forced expiratory volume in 1 second to predicted value(FEV_(1)% pred),and the percentage of forced expiratory volume in 1 second to forced vital capacity(FEV_(1)/FVC)were measured by spirometer.Results Compared with the control group,the relative expression level of lncRNA IL-6-AS1 was(1.43±0.13)in patients with chronic obstructive pulmonary disease and(1.73±0.17)in patients with acute exacerbation,and the expression level was significantly up-regulated.PEF%pred,FEV_(1)% pred and FEV_(1)/FVC were significantly decreased in COPD patients compared with the control group.The results of correlation analysis indicated that lncRNA IL-6-AS1 was negatively correlated with PEF% pred,FEV_(1)% pred and FEV_(1)/FVC.Conclusion Serum lncRNA IL-6-AS1 level is highly expressed in elderly COPD patients and is associated with decreased pulmonary function.LncRNA IL-6-AS1 may be a potential molecular target for clinical diagnosis and treatment of COPD.
作者 赵寅生 张辉 管涛 毛文凯 曲毅 ZHAO Yin-sheng;ZHANG Hui;GUAN Tao;MAO Wen-kai;QU Yi(Department of cardiothoracic surgery,Qinghai cardiovascular and cerebrovascular disease hospital,Xi’ning,Qinghai 810012,China)
出处 《临床肺科杂志》 2022年第6期870-873,共4页 Journal of Clinical Pulmonary Medicine
基金 青海省卫生健康委员会指导性课题(No.2018-wjwdx-37) 青海省科学技术厅(No.9632019Y0525)。
关键词 慢阻肺 LncRNA IL-6-AS1 肺功能 相关性分析 COPD lncRNA IL-6-AS1 lung function correlation analysis
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