地西他滨联合低剂量CAG化疗方案治疗老年复发性/难治性急性髓系白血病的效果及安全性

Efficacy and safety of decitabine combined with low-dose CAG chemotherapy in elderly patients with relapsed/refractory acute myeloid leukemia

目的:研究用地西他滨联合低剂量CAG化疗方案治疗老年复发性/难治性急性髓系白血病(AML)的效果及安全性。方法:选择2018年1月至2020年1月期间重庆市合川区人民医院收治的60例老年复发性/难治性AML患者作为研究对象。按照随机数表法将其分为常规化疗组和地西他滨组,每组各有患者30例。用低剂量CAG化疗方案对常规化疗组患者进行治疗,用地西他滨联合低剂量CAG化疗方案对地西他滨组患者进行治疗,然后比较两组患者的临床疗效、血常规指标及不良反应的发生率。结果:地西他滨组患者治疗的总有效率高于常规化疗组患者,P<0.05。治疗后,地西他滨组的白细胞(WBC)计数、血小板(PLT)计数和血红蛋白(Hb)的水平均高于常规化疗组患者,P<0.05。治疗期间,两组患者不良反应的发生率相比,P>0.05。结论:用地西他滨联合低剂量CAG化疗方案对老年复发性/难治性AML患者进行治疗的效果显著,能有效缓解其病情,改善其血细胞的水平,且治疗的安全性较高。

Objective:To study the efficacy and safety of decitabine combined with low-dose CAG chemotherapy in the treatment of elderly patients with relapsed/refractory acute myeloid leukemia(AML).Methods:SIXTY elderly patients with relapsed/refractory AML who were admitted to Chongqing Hechuan District People’s Hospital from January 2018 to January 2020 were selected as the study subjects.They were divided into conventional chemotherapy group and decitabine group according to random number table method,with 30 patients in each group.Patients in the conventional chemotherapy group were treated with low-dose CAG chemotherapy regimen,and patients in the decitabine group were treated with decitabine combined with low-dose CAG chemotherapy regimen,and then the clinical efficacy,blood routine indicators and the incidence of adverse reactions of the two groups were compared.Results:The total effective rate of decitabine group was higher than that of conventional chemotherapy group,P<0.05.After treatment,white blood cell(WBC)count,platelet(PLT)count and hemoglobin(Hb)level in decitabine group were higher than those in conventional chemotherapy group,P<0.05.During treatment,the incidence of adverse reactions in 2 groups was compared,P>0.05.Conclusions:Sitabine combined with low-dose CAG chemotherapy has a significant effect on the treatment of elderly patients with relapsed/refractory AML,which can effectively relieve the disease and improve the blood cell level,and has a high safety of treatment.