摘要
由于毒性低、疗效好、易获得等优点,天然产物已成为治疗一些疾病的重要药物来源。来源自蝎子的蝎毒肽已用于治疗自身免疫等多种疾病,其主要机制是通过抑制离子通道而产生治疗作用,Kv1.3通道是其主要作用靶点。本文总结了蝎毒肽作为阻滞剂作用于Kv1.3离子通道治疗自身免疫性疾病、肿瘤、炎症、凝血等方面的研究进展,并阐述了其作用机制,以期为蝎毒肽的进一步的开发利用提供依据。
Due to the advantages of low toxicity, good efficacy and easy access, natural products have become an important source of drugs for the treatment of some diseases. Scorpion venom peptide from scorpion has been used to treat many diseases such as autoimmunity. Its main mechanism is to produce therapeutic effect by inhibiting ion channels, and Kv1.3 channel is its main target. This paper summarized the scorpion venom peptide as blockers in Kv1.3ion channels in the treatment of autoimmune diseases, cancer, inflammation, blood clotting, research progress of and its mechanism of action, in order to provide the basis for the further development and utilization of scorpion venom peptide.
作者
李艳灵
赵婷婷
魏艳平
夏梦瑶
吴硕
马艳
魏永利
孙鹏
冯玉
Li Yanling;Zhao Tingting;Wei Yanping;Xia Mengyao;Wu Shuo;Ma Yan;Wei Yongli;Sun Peng;Feng Yu(School of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;School of Foreign Languages,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;College of Chemistry and Chemical Engineering,Qilu University of Technology,Jinan 250353,China;Department of Pharmacy,Affiliated Hospital of Shandong University cf Traditional Chinese Medicine,Jinan 250355,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2021年第12期4632-4640,共9页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会面上项目(81874419):ATP/P2X7R-NLRP3炎性小体通路介导的神经可塑受损在肝疏泄失常怒情志中的作用及机制研究,负责人:孙鹏
山东省科学技术厅山东省重点研发计划(2018GSF119022):医疗机构制剂“四虫胶囊”的研制,负责人:魏永利
山东省卫生健康委员会山东省中医药科技发展计划(2017-081):基于仿生酶解技术的全蝎抗肿瘤有效部位研究,负责人:魏永利。
关键词
蝎毒肽
Kv1.3通道
阻滞剂
研究进展
Scorpion venom peptide
Kv1.3 channel
Blockers
Research progress
