精神分裂症、双相情感障碍和抑郁症的跨疾病miRNA分子标记研究进展

Research progress of cross-disease miRNA molecular markers in schizophrenia, bipolar disorder and depression

微小非编码RNA(microRNA,miRNA)作为参与基因表达调控的非编码小RNA,在精神疾病的发生发展中发挥重要效应。有证据表明,精神疾病患者存在miRNAs表达失调。由于其在外周血、脑脊液中的稳定性与可定量检测性,miRNA是极具吸引力的生物标志物。本文旨在探讨精神疾病与miRNAs之间的关系以及miRNAs参与疾病发生的可能机制,重点关注3种常见的高致残、高致死性的精神障碍,即精神分裂症、双相情感障碍和抑郁症,综述从各疾病特有的失调miRNA分子到跨疾病的共同失调miRNA。本文总结了2016年至2020年相关研究积累的证据,并探究了一些显著失调的miRNA的功能以及miRNA在精神病学研究领域的应用前景。

Micro non-coding RNA(microRNA,miRNA)is a small non-coding RNA involved in gene expression regulation that plays an important role in the onset and development of mental illness.Evidence suggests that several miRNAs are dysregulated in patients with mental illnesses.Because of its stability and quantitative detection in peripheral blood and cerebral fluid,miRNA is a particularly attractive biomarker.The objective of this research is to investigate the relationship between mental illness and miRNAs,as well as the potential processes through which miRNAs contribute to disease etiology.Schizophrenia,bipolar disorder,and depression are three major mental disorders with high disability and mortality.The study explored the particular dysregulated miRNAs for each condition as well as common dysregulated miRNAs across diseases.In this study,which analyzes the findings from relevant studies from 2016 to 2020,the authors discuss the functions of numerous severely dysfunctional miRNAs and their application potential in the field of psychiatry research.