摘要
多种血液系统疾病可累及肝脏,并导致复杂多样的临床表现,如高非结合型胆红素血症、单克隆性免疫球蛋白升高、门静脉或肝静脉血栓形成/门静脉高压、肝脾肿大及肝脏铁沉积等临床表现。现简要论述常见溶血性疾病、凝血和抗凝因子缺陷、骨髓增殖性肿瘤、噬血细胞综合征、多发性骨髓瘤、白血病、淋巴瘤等血液系统疾病的肝脏表现,以帮助临床医生更好诊治此类疾病。
Liver involvement is often observed in hematological disorders,resulting in liver abnormality,including unconjugated hyperbilirubinemia,monoclonal hyperglobulinemia,portal vein,or hepatic vein thrombosis or portal hypertension,hepatosplenomegaly,or iron accumulation in the liver.Here we summarize the major hematological diseases that often affect the liver:hemolytic anemia,defect in coagulation or anti-coagulation factors,myeloproliferative neoplasm,hemophagocytic lymphohistiocytosis,multiple myeloma,leukemia,and lymphoma.We hope this review will help clinicians diagnose and manage the patients with liver involvement by hematological disorders.
作者
单姗
赵新颜
贾继东
Shan Shan;Zhao Xinyan;Jia Jidong(Liver Research Center,Beijing Friendship Hospital,Capital Medical University Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis&National Clinical Research Center for Digestive Diseases,Beijing 100050,China)
出处
《中华肝脏病杂志》
CSCD
北大核心
2022年第4期347-351,共5页
Chinese Journal of Hepatology
基金
国家自然科学基金(82000569)。
关键词
血液病
肝脏疾病
肝脏表现
Hematopathy
Liver disease
Liver manifestation