摘要
免疫球蛋白(Ig)G4相关疾病是一种免疫介导的累及多个器官的慢性纤维炎性疾病。IgG4相关肝胆胰疾病是IgG4相关疾病在肝胆胰系统中的表现,以血清IgG4滴度升高、病变组织中大量IgG4阳性浆细胞浸润、组织纤维化、影像学器官形态改变等为主要特点,因缺乏可靠的生物标志物,组织病理学仍是诊断的重要依据。IgG4相关肝胆胰疾病发病机制尚未完全明确,现重点报道IgG4相关肝胆胰疾病近年来在肠道微生态-免疫学、宿主遗传-免疫及复发监测领域的进展。
IgG4-related disease(IgG4-RD)is an immune-mediated condition associated with chronic fibroinflammatory lesions that can affect nearly any organ.IgG4-related hepatobiliary and pancreatic diseases are IgG4-RD involving the hepatobiliary and pancreatic system,which is characterized with elevated serum IgG4 concentrations,large numbers of IgG4 positive lymphoplasma cells infiltration in affected organs,storiform fibrosis,and imaging changes of organ morphology.Due to the lack of reliable biomarkers,histopathology is still an important basis for diagnosis.The pathogenesis of IgG4-related hepatobiliary and pancreatic diseases has not been clarified.This review focuses on the recent advances in intestinal microecology-immunology,host genetics-immunity and recurrence monitoring of IgG4-related hepatobiliary and pancreatic diseases.
作者
潘厦厦
吴仲文
Pan Xiaxia;Wu Zhongwen(State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Centre for Infectious Diseases,Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310000,China)
出处
《中华肝脏病杂志》
CSCD
北大核心
2022年第4期452-456,共5页
Chinese Journal of Hepatology
基金
国家重点研发计划(2018YFC200050):国家自然科学基金(32170058)。
