维生素D对多发性硬化患者预后的影响

The Effect of Vitamin D on the Prognosis of Patients with Multiple Sclerosis

目的 探讨维生素D对多发性硬化患者预后的影响。方法 选取58例多发性硬化患者为研究对象,随机分为研究组与对照组。对照组患者给予糖皮质激素进行治疗,研究组患者在糖皮质激素治疗的基础上给予维生素D。干预并随访18月后观察与比较两组患者Kurtzke扩展残疾状况量表(EDSS)评分、不良反应、复发情况及生活质量。结果 干预前与干预6月时两组患者EDSS评分间没有统计学差异;干预12月时与干预18月时研究组患者的EDSS评分均明显少于对照组。干预期间研究组患者的不良反应及复发率均明显低于对照组;干预后研究组患者的生活质量明显高于对照组。结论 维生素D不仅能明显改善多发性硬化患者的神经功能,还能降低患者的不良反应的发生率和复发率,提高患者的生活质量,值得在临床工作中进行应用与推广。

Objective To investigate the effect of vitamin D on the prognosis of patients with multiple sclerosis. Methods Fiftyeight patients with multiple sclerosis were selected as the research objects and were randomly divided into study group and control group. Patients in the control group were treated with glucocorticoids, and patients in the study group were treated with vitamin D on the basis of glucocorticoid treatment. After intervention and follow-up for 18 months, the Kurtzke Extended Disability Status Scale(EDSS) scores, adverse reactions, recurrences, and quality of life were observed and compared between the two groups. Results There was no statistical difference between the EDSS scores of the two groups of patients before and after the intervention for 6months;the EDSS scores of the study group were significantly lower than those of the control group after 12 months of intervention and after 18 months of intervention. During the intervention period, the adverse reactions and recurrence rates of the study group were significantly lower than those of the control group;after the intervention, the quality of life of the study group was significantly higher than that of the control group. Conclusion Vitamin D can not only significantly improve the neurological function of patients with multiple sclerosis, but also reduce the incidence and recurrence rate of adverse reactions in patients, as well as improve the quality of life of patients. It is worthy of application and promotion in clinical work.