摘要
Functionalized nanoparticles are widely used in drug targeted delivery and immune microenvironment regulation.As a new type of biomaterial,cell-derived carriers are receiving considerable attention in clinical translation owing to their desirable biocompatibility and lower toxicity.Importantly,cell membrane-encapsulated nanoparticles can achieve specific biological effects from the benefit of their parent cell characteristics.In this review,we introduce the cell membrane coating technologies that are under extensive investigation,we also summarize various applications that have been developed for immunotherapy,and discuss the prospects in this field.With further understanding and integration with advanced biotechnology methods,it is believed that the continuing development of cell membrane-encapsulated nanoparticles will achieve promotion in clinical application.
基金
supported by the Major State Basic Research Development Program of China(grant No.2017YFA0205201)
the National Natural Science Foundation of China(grant Nos.81925019 and U1705281)
the Fundamental Research Funds for the Central Universities(grant Nos.20720190088 and 20720200019)
the Program for New Century Excellent Talents in University,China(grant No.NCET-13-0502)
Guangdong Basic and Applied Basic Research Foundation(grant No.2020A1515110456).
