首发性和复发性抑郁症伴认知功能障碍患者P300、血清FGF22水平的比较及其与认知功能、血清炎性因子的关系

Comparison of P300 and serum FGF22 levels between cognitive impairment patients with first-episode and recurrent depression and their relations with cognitive function and serum inflammatory factors

目的比较首发性和复发性抑郁症伴认知功能障碍患者的事件相关电位P300和血清成纤维细胞生长因子22(FGF22)水平的差异,分析各指标与认知功能、血清炎性因子的关系。方法选择江苏大学附属医院神经心理门诊自2020年6月至2021年4月收治的45例首发性抑郁症伴认知功能障碍患者(首发组)和42例复发性抑郁症伴认知功能障碍患者(复发组),均行P300检查并采用酶联免疫吸附实验(ELISA)检测患者血清FGF22、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,比较2组患者临床资料、P300检查结果和血清FGF22、IL-6、TNF-α水平的差异,相关性分析患者P300波幅、潜伏期及血清FGF22水平与其蒙特利尔认知评估量表(MoCA)评分、IL-6、TNF-α水平的相关性。结果与首发组比较,复发组患者的MoCA评分降低、P300波幅降低、P300潜伏期增加、血清FGF22水平降低,IL-6和TNF-α水平升高,差异均有统计学意义(P<0.05)。相关性分析显示患者P300波幅、血清FGF22水平与MoCA评分均呈正相关关系(P<0.05),与血清IL-6和TNF-α水平均呈负相关关系(P<0.05);P300潜伏期与MoCA评分呈负相关关系(P<0.05),与血清IL-6和TNF-α水平均呈正相关关系(P<0.05)。结论首发性和复发性抑郁症伴认知功能障碍患者P300波幅、P300潜伏期和血清FGF22水平不同,其与患者的认知功能和血清炎性因子水平有关。

Objective To compare the differences of event-related potential P300 and serum fibroblast growth factor 22(FGF22)levels in cognitive impairment patients with first-episode and recurrent depression,and analyze the relations of each index with cognitive function and serum inflammatory factors.Methods From June 2020 to April 2021,45 cognitive impairment patients with first-episode depression(first-episode group)and 42 cognitive impairment patients with recurrent depression(recurrence group)were selected from our hospital.P300 examination was performed and serum FGF22,interleukin 6(IL-6)and tumor necrosis factorα(TNF-α)levels were measured by enzyme-linked immunosorbent experiment(ELISA).The differences in clinical data,P300 examination results,and serum FGF22,IL-6 and TNF-αlevels were compared between the two groups.The correlations of P300 amplitude and latency and serum FGF22 level with Montreal Cognitive Assessment(MoCA)scores and IL-6 and TNF-αlevels were analyzed.Results As compared with the first-episode group,the recurrence group had significantly decreased MoCA scores,P300 amplitude and serum FGF22 level,and statistically increased P300 latency and IL-6 and TNF-αlevels(P<0.05).Correlation analysis showed that P300 amplitude and serum FGF22 level were positively correlated with MoCA scores,and negatively correlated with IL-6 and TNF-αlevels(P<0.05);P300 latency was negatively correlated with MoCA scores,and positively correlated with IL-6 and TNF-αlevels(P<0.05).Conclusion P300 amplitude and latency and serum FGF22 level are different between cognitive impairment patients with first-episode and recurrent depression,and they are correlated with the cognitive function and serum inflammatory factors.