促肾上腺皮质激素治疗婴儿痉挛症的临床和基础研究进展

Clinical and basic research progress of adrenocorticotropic hormone in treatment of infantile spasm

婴儿痉挛症(IS)是一种婴儿期常见的癫痫性脑病,典型表现为痉挛发作,精神发育迟缓和发作间期脑电图高度失律。促肾上腺皮质激素(ACTH)是IS的一线治疗药物,尽管其疗效目前已获广泛认可,但治疗方案尚不统一,治疗机制尚不明确。本文围绕ACTH治疗IS的临床应用和基础研究进展进行综述,旨在为ACTH治疗IS提供临床和理论依据。

Infantile spasm(IS)is a common epileptic encephalopathy in infancy,characterized by typical epileptic spasm,developmental delay and hypsarrhythmia on interictal electroencephalogram(EEG).Adrenocorticotropic hormone(ACTH)is the first-line treatment medicine for IS.Although ACTH has shown good response to IS and has been widely used,the regime is not identical and the mechanism is still unclear.This paper focuses on the clinical application of ACTH for IS and the anticonvulsant mechanisms of ACTH,in order to provide clinical and theoretical basis for ACTH application.