羊传染性脓疱病研究进展

Research Progress on Contagious Ecthyma in Sheep

羊传染性脓疱病是由羊传染性脓疱病毒(orf virus,ORFV)引起的传染性极强且流行广泛的人畜共患病。健康羊只感染ORFV后,会在唇、鼻和口腔等无毛部位依次形成丘疹、水疱、脓疱及溃疡,最后形成疣状结痂,产生增生性损伤。羔羊由于免疫系统发育不完全尤其易感,发病后会导致采食困难、营养物质摄入不足,进而影响生长发育,严重者会因继发性感染而死亡。结合近年来国内外研究报道,从病原学、流行病学、临床症状、诊断方法、预防和治疗措施等方面对羊传染性脓疱病进行综述,以期为兽医临床中该病的预防、诊断和治疗提供参考。

Sheep contagious ecthyma,caused by infection of orf virus(ORFV),is a highly contagious and widespread zoonosis.Healthy sheep infected with ORFV will develop papules,blisters,pustules and ulcers in consecutive order,and eventually verrucous scabs in the hairless areas such as lip,nose,and mouth,resulting in proliferative damage.Lambs are particularly susceptible due to incomplete development of their immune system.After the onset,lambs will have difficulty in feeding and malnutrition,which will affect their growth and development,and severe cases will die from secondary infection.This paper reviews the research progress on contagious ecthyma in sheep from the aspects of etiology,epidemiology,clinical symptoms,diagnostic methods,as well as prevention and treatment measures by referring the recent researches in China and abroad,in hoping to provide references for the prevention,diagnosis,and treatment of this disease in veterinary clinics.