基于数据挖掘与网络药理学分析陈可冀主编之清宫系列书籍治疗骨关节炎外用方的用药规律

Based on Data Mining and Network Pharmacology Analyse the Using Drugs Regularity of External Prescription for Osteoarthritis in Royal Formulary of the Qing Dynasty Edited by CHEN Ke-ji

目的:利用数据挖掘软件与网络药理学分析陈可冀院士主编的清宫系列书籍中治疗骨关节炎外用方的用药规律。方法:从清宫系列书籍中筛选出治疗骨关节炎的外用方剂,利用Excel软件建立数据库,基于中医传承辅助平台(V3.0)统计中药使用频次及其性味、归经、功效,再对方剂进行关联规则和聚类分析。在此基础上结合专业知识组出新方(荣筋祛痹方),再用网络药理学验证荣筋祛痹方治疗骨关节炎的可行性。结果:从清宫系列书籍中筛选出治疗骨关节炎的外用方剂103首,频数统计显示常见外用药物以乳香、当归、没药、防风等为主,多用性温、平,味辛、苦,入肝、脾经的中药,基于此分析中药的关联规则聚类出核心组合。综合上述结果组出新方(荣筋祛痹方)。结论:清宫系列书籍治疗骨关节炎的外用药主要以活血化瘀、祛风除湿为主,兼以补益肝肾。用药规律符合骨关节炎外因感受风寒湿邪、内因肝肾亏虚从而产生中间病理产物-瘀血的中医发病特点。由此分析聚类出的中药核心组合对骨关节炎的治疗用药具有参考价值,在此基础上用网络药理学验证过的新方(荣筋祛痹方)对骨关节炎具有治疗价值。

Objective:Analyzing the medication law of external prescriptions for the treatment of osteoarthritis in royal formulary of the Qing dynasty books edited by academician CHEN Ke-ji by using data mining software and network pharmacology.Methods:Selected the external prescriptions for the treatment of osteoarthritis from the books,and use excel software to build a database,based on the TCM inheritance assistance platform(V3.0),the frequency of TCM use and its taste,meridian and efficacy were counted,and then the association rules and clusters of prescriptions were analyzed.Combined with professional knowledge,a new formula(Rongjinqubi prescription)was formed,and the feasibility of Rongjinqubi prescription in the treatment of osteoarthritis was proved by the network pharmacology.Result:Based on 103 external prescriptions for the treatment of osteoarthritis was selected from the books and the frequency statistics showed that the common topical drugs were mainly Frankincense,Angelica sinensis,Myrrh and Fangfeng,etc.Whose the tropism of taste was warm,flat,spicy,bitter,into the liver,spleen.Based on this analysis,the core combinations were clustered according to the association rules of TCM.Comprehensive the results above set new prescription(Rongjinqubi prescription).Conclusion:Royal formulary of the Qing Dynasty series of books for the treatment of osteoarthritis is mainly to promote blood circulation and remove blood stasis,dispel wind and dehumidification,and to tonifying the liver and kidney.Using drugs'regularity is consistent with the characteristics of the pathogenesis of osteoarthritis in TCM,which generates the intermediate pathological product of blood stasis due to the experience of wind chill and dampness,liver and kidney deficiency due to internal causes.Based on this analysis,the core combination of TCM clustering has a reference value for the treatment of osteoarthritis.On this basis,the new prescription(Rongjinqubi prescription)verified by network pharmacology provides therapeutic value for the treatment of osteoarthritis.