摘要
RNA结合蛋白HuR(human antigen R),又被称为类胚胎致死性异常视觉基因1(ELAV like RNA binding protein 1,ELAV1),是一种在机体各组织中广泛表达的重要RNA结合蛋白,其通过调控mRNA前体剪接、多聚腺苷酸化,以及mRNA稳定性与翻译效率等方式参与机体各项生命活动。研究表明,RNA结合蛋白参与了肌肉生长发育调控,其中HuR主要通过影响靶mRNAs的稳定性和翻译参与调控肌生成与肌肉疾病的发生。本文结合近年来HuR的相关研究,从HuR的生物学特性、主要功能与作用方式、在肌肉生长发育及肌肉疾病中的调控作用等方面展开综述,以期为进一步研究HuR在肌肉生长发育调控中的作用提供参考。
The RNA binding protein HuR(human antigen R),also known as ELAV like RNA binding protein 1(ELAV1),is an important RNA binding protein widely expressed in various tissues of the body,which is involved in various biological activities through the regulation of pre-mRNA splicing,polyadenylation,as well as mRNA stability and translational efficiency.Studies have shown that RNA binding proteins are involved in the regulation of muscle growth and development,in which HuR is involved in regulating myogenesis and the occurrence of muscle diseases mainly by affecting the stability and translation of target mRNAs.Combined with the related research of HuR in recent years,this paper reviews the biological characteristics,main functions and modes of action of HuR,and its regulatory role in muscle growth and development and related diseases,in order to provide reference for the further study of the role of HuR in the regulation of muscle growth and development.
作者
孙严金
薛亚男
仲涛
王林杰
李利
张红平
占思远
SUN Yanjin;XUE Ya’nan;ZHONG Tao;WANG Linjie;LI Li;ZHANG Hongping;ZHAN Siyuan(Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China)
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2022年第5期1345-1353,共9页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然科学基金(32002163)。
关键词
HUR
功能
肌肉生长发育
疾病
作用机制
HuR
function
muscle growth and development
disease
mechanism of action
