恶性疟原虫ApiAP2蛋白质家族研究进展

Research Advance on ApiAP2 Family of Plasmodium falciparum

疟疾是由顶复门寄生虫——疟原虫引起的一种人畜共患病。疟原虫不仅可以感染人,还能够感染家禽、鼠、食蟹猴等多种动物,其中,鸡疟原虫病、鼠疟原虫病对畜牧业影响较大。为完成其复杂的生命周期,疟原虫需要严格的基因调控,而转录因子对基因表达的调控作用十分关键。截至目前,ApiAP2蛋白质家族是在所有顶复门原虫中作为候选转录因子出现的唯一蛋白质家族。论文在总结已有研究的基础上,预测恶性疟原虫ApiAP2蛋白质家族中未知功能蛋白质的调控机制,并开展对ApiAP2蛋白质家族发生蛋白质翻译后修饰功能的展望,为畜牧业研发原虫病疫苗提供借鉴与参考。

Malaria is a zoonosis caused by Plasmodium which belongs to Apicomplexan.Plasmodium can not only infect human beings,but also poultries,mice,cynomolgus macaques and many kinds of animals,among which Plasmodium gallinaceum and rodent malaria have a great impact on animal husbandry.Plasmodium requires a strict gene regulation to complete its complex life cycle and transcription factors play very essential roles in regulating gene expression.Up to now,apicomplexan AP2(ApiAP2)family is the only candidate that appears as transcription factors in Apicomplexan.On the basis of summarizing the previous studies,this article predicts the regulatory mechanism that the function of proteins is unknown in ApiAP2 family of Plasmodium falciparum,also explores the prospect of the post-translational modification in ApiAP2 family,which provides reference for animal husbandry to develop vaccine of protozoal diseases.