摘要
The amyloid cascade hypothesis of Alzheimer’s pathogenesis:The amyloid cascade hypothesis of Alzheimer’s disease(AD)pathogenesis will shortly celebrate its thirtieth birthday(Hardy and Higgins,1992).Based on abundant genetic and biochemical evidence,it proposes that deposition of the amyloid-β(Aβ)peptide in brain parenchyma is an essential upstream trigger in AD pathogenesis that drives a cascade of events,specifically including the recruitment and pathological hyper-phosphorylation of the micro-tubule-associated protein tau,that culminate in derangement of synaptic function and,eventually,neuronal death.
