肠道菌群调控慢性疼痛机制的研究进展

Progress in research on the mechanisms of pain regulation by microbiota

近年来,肠道菌群与肠-脑轴的相互作用逐渐被认识,肠道菌群参与调控神经系统相关疾病的机制也日益被关注,其中肠道菌群可参与调控多种慢性疼痛,包括内脏痛、炎性痛、神经病理性疼痛和头痛等。肠道菌群本身的成分以及其代谢产物和副产物会通过调控多种细胞信号通路及神经递质干预慢性疼痛的发生和发展。本文对已发表的肠道菌群调控慢性疼痛的相关研究进行了广泛检索及总结,并在此基础上综述肠道菌群参与慢性疼痛的机制,以期为研发通过调控肠道菌群而发挥镇痛作用的靶点药物提供理论基础。

Recent years,the interaction between gut microbiota and brain gut axis has been gradually recognized,the relationship between gut microbiota and neurological diseases,including chronic pain,has received increasing attention.Gut microbiome plays a critical role in many types of chronic pain,including visceral pain,inflammatory pain,neuropathic pain and headache.Numerous signaling molecules derived from gut microbiota,such as by-products of microbiota,metabolites,neurotransmitters and neuromodulators,act on their receptors and remarkably regulate the peripheral and central sensitisation.In this study,the published researches on chronic pain regulated by microbiota have been extensively retrieved and summarized.On this basis,the possible mechanism of pain regulation by microbiota is summarized for the purpose to provide theoretical basis for the development of target drugs for microbiota regulation.