妊娠期体重增加与后代成年超重和肥胖发生风险:系统综述和Meta分析

Association between gestational weight gain and the risk of overweight/obesity in adult offspring:a systematic review and meta-analysis

目的采用系统综述和Meta分析的方法评估妊娠期体重增加与后代成年超重和肥胖发生风险之间的相关性。方法在线检索PubMed、Web of Science、Embase、中国知网(CNKI)、维普及万方等数据库从建库至2021年7月24日前发表的有关妊娠期体重增加与后代成年超重和肥胖发生关联的文献,并人工检索纳入文献的参考文献列表。使用随机效应模型计算合并RR和95%CI值。通过亚组分析和敏感性分析,探索异质性的可能来源,并评估结果的稳健性。结果本研究共纳入6项研究,共计31968人。结果显示:妊娠期体重增加过多会增加后代成年超重和肥胖发生风险(RR=1.37,95%CI:1.24~1.52,P<0.001),妊娠期体重增加不足与后代成年超重和肥胖发生风险无关(RR=0.93,95%CI:0.78~1.11,P=0.430)。结论妊娠期体重增加过多会增加后代成年超重和肥胖的发生风险,应注意均衡膳食摄入及适量运动,避免妊娠期体重增加过多。

Objective To evaluate the association between gestational weight gain(GWG)and the risk of overweight/obesity in adult offspring by systematically reviewing and Meta analyzing.Methods A systematic literature search was performed in the PubMed,Web of Science,Embase,China National Knowledge Infrastructure,Wanfang,and Weipu databases from inception to June 2,2021,for relevant articles on the association between GWG and the risk of overweight/obesity in adult offspring,complementing with a perusal of bibliographies of retrieved articles.The overall risk ratio(RR)and 95%confidence intervals(CI)were calculated using a random-effects model.Subgroup and sensitivity analyses were performed to explore possible sources of heterogeneity and assess the robustness of the results.Results Six studies with a total of 31968 individuals were included in this study.Results showed that a statistically significant association was found between excessive GWG and the risk of overweight and obesity in adult offspring(RR=1.37,95%CI:1.24-1.52,P<0.001).No significant association was obtained between inadequate GWG and the risk of overweight and obesity in adult offspring(RR=0.93,95%CI:0.78-1.11,P=0.430).Conclusions Excessive GWG will increase the risk of overweight and obesity in adult offspring.Therefore,pregnant women should pay attention to a balanced diet and exercise moderately to avoid excessive weight gain during pregnancy.