血清微囊藻毒素-LR水平与原发性肝癌临床病理特征的关系

Relationship between serum microcystin-LR levels and clinicopathological characteristics of primary liver cancer

目的:探讨血清微囊藻毒素-LR(MC-LR)水平与原发性肝癌临床病理特征之间的关系,为肝癌的预防和控制提供科学依据。方法:选取2016年12月至2021年7月在广西医科大学附属肿瘤医院就诊的原发性肝癌患者405例作为肝癌组,411例同期体检的健康者作为对照组。收集研究对象的一般人口学及临床资料,采用酶联免疫吸附试验检测研究对象血清MC-LR水平。结果:肝癌组血清MC-LR水平高于对照组[(0.18±0.09)ng/mL vs(0.12±0.06)ng/mL,P<0.01]。与MC-LR低暴露组(<0.14 ng/mL)相比,MC-LR高暴露组(≥0.14 ng/mL)人群发生肝癌风险明显增加(校正OR=2.81,95%CI:1.78~4.43,P<0.001)。肿瘤直径≥5 cm、多发、BCLC分期为C~D期、低分化、出现淋巴结转移、远处转移或侵犯门静脉者,血清MC-LR水平较高(均P<0.05)。结论:MC-LR高暴露可能增加原发性肝癌发病风险,肝癌患者血清MC-LR水平与肿瘤直径及数量、分化程度、BCLC分期、淋巴结转移等临床病理特征相关。

Objective:To explore the relationship between serum microcystin-LR(MC-LR)level and the clinicopathological characteristics of primary liver cancer,and to provide a scientific basis for the prevention and control of the disease.Methods:A total of 405 patients with primary liver cancer treated in the Affiliated Tumor Hospital of Guangxi Medical University from December 2016 to July 2021 were enrolled as the liver cancer group,and 411 healthy individuals undergoing physical examination at the same period were selected as the control group.The general demographic and clinical data of the study subjects were collected,and the serum MC-LR level was detected by enzyme-linked immunosorbent assay.Results:Serum MC-LR level in the liver cancer group was higher than that in the control group[(0.18±0.09)ng/mL vs.(0.12±0.06)ng/mL,P<0.01].The risk of liver cancer was significantly increased in the population with high MC-LR exposure(≥0.14 ng/mL)compared with the low MC-LR exposure group(<0.14 ng/mL)(corrected OR=2.81,95%CI:1.78-4.43,P<0.001).Serum MC-LR level was higher in those with tumor diameter≥5 cm,multiple tumors,BCLC stage C-D,low differentiation,presence of lymph node metastasis,distant metastasis or invasion of portal vein(P<0.05).Conclusion:High MC-LR exposure may increase the risk of primary liver cancer,and serum MC-LR level in patients with liver cancer is correlated with clinicopathological characteristics such as tumor diameter and number,differentiation,BCLC stage,and lymph node metastasis.