胸腺基质淋巴生成素对肺部2型淋巴细胞的致敏作用研究进展

The sensitization of thymic stromal lymphopoietin to type 2 lymphocytes in the lung

胸腺基质淋巴生成素(thymic stromal lymphopoietin,TSLP)可通过直接作用和间接作用两种途径在肺部增强2型T辅助(type 2 T helper,Th2)细胞和2型先天淋巴细胞(type 2 innate lymphocytes,ILC2s)分泌2型细胞因子。在间接作用方面,TSLP可利用树突状细胞促进幼稚CD4+T细胞增殖和扩增,促进Th2细胞招募到最初的炎症部位;还可利用间质单核细胞/巨噬细胞启动急性原发性Th2依赖性免疫反应。在直接作用方面,TSLP可在适应性免疫反应启动之前激活ILC2s,也可利用幼稚T细胞、效应Th2细胞和记忆性Th2细胞参与适应性免疫反应。因此,TSLP对肺部过敏性免疫反应起着重要作用。

Thymic stromal lymphopoietin(TSLP)can enhance the secretion of type 2 cytokines by type 2 T helper(Th2)cells and type 2 innate iymphocytes(ILC2s)in the lung through direct and indirect action.In terms of indirect effects,TSLP can promote the proliferation and expansion of naive CD4+T cells by using dendritic cells,and promote the recruitment of Th2 cells to the initial inflammatory site.It can also use stromal mononuclear/macrophages cells to start the acute primary Th2-dependent immune response.In the aspect of direct effect,TSLP can activate ILC2s before the adaptive immune response is initiated,and also can use immature T cells,effector Th2 cells and memory Th2 cells to participate in the adaptive immune response.Therefore,TSLP plays an important role in allergic immune response of lung.