基因多态性与新生儿迁延性黄疸研究进展

Progress on the gene polymorphism and prolonged neonatal jaundice

部分新生儿黄疸患儿可出现迁延性黄疸,黄疸消退延迟,可持续2~3个月。其严重并发症为核黄疸,表现为不可逆的神经系统损伤,故新生儿黄疸已成为全球关注的问题。目前新生儿迁延性黄疸的发病机制尚不明确,近年来研究发现,遗传因素与新生儿迁延性黄疸密切相关,该文就常见的基因多态性与新生儿迁延性黄疸的研究进展进行综述。

Some children with neonatal jaundice may have prolonged neonatal jaundice,and the regression of jaundice is delayed for 2~3 months.The severe complication is nuclear jaundice,which is manifested as irreversible nervous system damage.Therefore,neonatal jaundice has become an important global concern problem.At present,the pathogenesis of prolonged neonatal jaundice is not clear.Recent studies have found that genetic factors are closely related to prolonged neonatal jaundice.In this review,the research progress of common gene polymorphism and prolonged neonatal jaundice are summarized.