探究胞二磷胆碱针剂联合丹红注射液治疗脑后循环缺血性眩晕患者的临床疗效

To explore the clinical effect of citicoline injection combined with Danhong injection on patients with ischemic vertigo in posterior circulation

目的探究胞二磷胆碱针剂联合丹红注射液治疗后循环缺血性眩晕患者的临床疗效。方法回顾性选取2018年6月至2019年12月西安高新医院神经内科收治的96例后循环缺血性眩晕患者,按照治疗方式不同将患者分为观察组和对照组,每组各48例。所有患者均行常规治疗,对照组患者单纯应用胞二磷胆碱针剂(0.5 g)治疗,观察组患者在此基础上额外给予丹红注射液(30 m L)治疗,每日1次。连续治疗2周后,比较两组患者眼震电图缓解情况、血小板衍生生长因子-BB(PDGF-BB)、一氧化氮合酶(NOS)水平及经颅多普勒(TCD)血流速度变化及疗效情况。结果治疗2周后,观察组患者治疗总有效率为95.83%,高于对照组(81.25%),差异有统计学意义(P<0.05)。治疗2周后,两组患者眼震电图积分均较治疗前降低,观察组患者眼震图积分(1.99±0.83)分,低于对照组[(3.04±1.21)分],差异有统计学意义(P<0.05)。治疗2周后,两组患者PDGF-BB、NOS均较治疗前降低,观察组PDGF-BB、NOS含量为(34.04±5.45)pg/m L、(35.95±5.39)U/L,均低于对照组[(40.79±5.95)pg/m L、(41.07±6.42)U/L],差异均有统计学意义(P<0.05)。治疗2周后,观察组患者左侧椎动脉、右侧椎动脉、基底动脉血流速度为(31.42±4.98)、(29.23±5.23)、(41.07±4.92)cm/s,显著优于对照组[(25.85±4.56)、(25.36±4.42)、(34.48±5.03)cm/s],差异均有统计学意义(P<0.05)。观察组与对照组患者不良反应发生率比较(6.25%vs.8.33%),差异无统计学意义(P>0.05)。结论胞二磷胆碱针剂联合丹红注射液对后循环缺血性眩晕患者眼震电图积分、PDGF-BB、NOS水平及TCD血流速度变化具有更好的改善作用,安全性确切且患者临床疗效更佳,值得推广。

Objective To explore the clinical effect of citicoline injection combined with Danhong injection on patients with posterior circulation ischemic vertigo.Methods A retrospective selection of 96 patients with posterior circulation ischemic vertigo admitted to the Department of Neurology of Xi’an High-tech Hospital from June 2018 to December 2019 were divided into observation group and control group according to the different treatment methods adopted by the patients,48 patients in each group.All patients received conventional treatment.The patients in the control group were treated with citicoline injection( 0.5 g) alone,and the patients in the observation group were additionally treated with Danhong injection( 30 m L) once a day.After continuous treatment for 2 weeks,the remission of electronystagmus,PDGF-BB and NOS levels,transcranial doppler( TCD) blood flow velocity changes and curative effects were compared between the two groups.Results After 2 weeks treatment,the total effective rate of the observation group was 95.83%,which was higher than that of the control group( 81.25%),and the difference was statistically significant( P < 0.05).After 2 weeks of treatment,the electronystagmogram scores of the two groups were lower than those before treatment,and the electronystagmogram scores in the observation group was( 1.99 ± 0.83) points,which was lower than those in the control group[( 3.04 ± 1.21) points],and the differences was statistically significant significance( P < 0.05).After 2 weeks of treatment,the levels of PDGF-BB and NOS in two groups were lower than those before treatment,and the levels of PDGF-BB and NOS in observation group were( 34.04± 5.45) pg/m L and( 35.95 ± 5.39) U/L,which were lower than those in the control group [( 40.79 ± 5.95) pg/m L,( 41.07 ± 6.42) U/L],the differences were statistically significant( P < 0.05).After 2 weeks of treatment,the blood flow velocities of the left vertebral artery,right vertebral artery and basilar artery in the observation group were( 31.42 ± 4.98),( 29.23 ± 5.23),and( 41.07 ± 4.92) cm/s,which were significantly better than those in the control group.[( 25.85 ± 4.56),( 25.36 ± 4.42),( 34.48 ± 5.03) cm/s],the differences were statistically significant( P < 0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group( 6.25% vs.8.33%)( P > 0.05).Conclusion Citicoline injection combined with Danhong injection can better improve electronystagmogram scores,PDGF-BB,NOS level and TCD blood flow velocity changes in patients with posterior circulation ischemic vertigo.It is safe and clinical.The curative effect is better and it is worth promoting.