miR-146b在胃癌组织中的表达及其与临床病理特征的关系

Expression of miR-146b in gastric cancer and its relationship with clinicopathological characteristics

目的 探讨miR-146b在胃癌组织及配对癌旁组织中的表达水平及其与临床病理特征的关系。方法 采用实时荧光定量PCR法测定40例首诊胃癌患者胃癌组织和配对癌旁组织中miR-146b的表达水平,并分析其表达水平的变化与临床病理特征的关系。结果 miR-146b在胃癌组织中的相对表达水平明显低于配对癌旁组织,差异有统计学意义(P<0.01);不同年龄、肿瘤分化程度、临床分期、是否有淋巴结转移胃癌患者胃癌组织miR-146b相对表达水平比较,差异均有统计学意义(P<0.05)。结论 miR-146b在胃癌组织中的表达明显下调,可能为胃癌的诊断与靶向治疗提供依据。

Objective To investigate the expression level of miR-146 b in gastric cancer tissues and its relationship with clinicopathological characteristics.Methods Real-time fluorescence quantitative PCR was used to determine the relative expression levels of miR-146 b in gastric cancer tissues and paracancer tissues of 40 patients diagnosed with gastric cancer for the first time,and the relationship between the change of miR-146 b expression level and clinicopathological characteristics was analyzed.Results The relative expression level of miR-146 b in gastric cancer tissues was lower than that in paired paracancer tissues,and the difference was statistically significant(P<0.01).There were statistically significant differences in the relative expression levels of miR-146 b in gastric cancer tissues of patients with different age,tumor differentiation degree,clinical stage and whether there was lymph node metastasis or not(P<0.05).Conclusion The expression level of miR-146 b was significantly down-regulated in gastric cancer tissues,which may provide evidence for the diagnosis and targeted therapy of gastric cancer.