慢性心力衰竭并发静脉血栓患者vWF活性与其基因多态性及民族的相关性研究

Relationship between vWF activity,gene polymorphism and nationalities in patients with chronic heart failure complicated with venous thrombosis

目的 分析慢性心力衰竭(CHF)并发静脉血栓患者血管性血友病因子(vWF)基因rs7966230多态性位点基因型分布特点及与其vWF活性和民族的相关性。方法 将2017年3月至2020年3月来该院就诊的42例CHF并发下肢静脉血栓患者作为CHF并发血栓组,将同期来该院体检的104例体检健康者作为健康对照组,观察两组vWF基因rs7966230(G/C)基因型及vWF活性。采用Pearson相关分析CHF并发静脉血栓患者血浆vWF活性与其基因型及民族的相关性。结果 与健康对照组相比,CHF并发血栓组患者vWF基因rs7966230多态性位点的基因型和等位基因的分布差异均无统计学意义(P>0.05)。CHF并发血栓组患者vWF基因rs7966230 GC基因型vWF活性明显高于CC型(P<0.05),而各民族不同基因型vWF活性比较,差异无统计学意义(P>0.05)。CHF并发静脉血栓患者血浆vWF活性与rs7966230位点基因呈正相关(r=0.433,P=0.034),而与民族无明显相关性(r=-0.017,P=0.913)。结论 CHF并发静脉血栓患者的血浆vWF活性与rs7966230位点基因型有相关性,与民族无明显相关性。

Objective To analyze the distribution characteristics of von willebrand factor(vWF) rs7966230 and its relationship with vWF activity and nationality in patients with chronic heart failure(CHF) complicated with venous thrombosis.Methods From March 2017 to March 2020,42 patients with CHF complicated with lower limb venous thrombosis in this hospital were enrolled as the heart failure complicated with thrombosis group,and 104 healthy subjects were enrolled as the healthy control group.VWF rs7966230(G/C) genotype and vWF activity of the two groups were detected.Pearson correlation was used to analyze the correlation between plasma vWF activity and genotype and nationality in patients with CHF complicated with venous thrombosis.Results Compared with the healthy control group,there was no significant difference in the distribution of genotype and allele of rs7966230 polymorphism of vWF gene in patients with CHF complicated with venous thrombosis(P>0.05).The vWF activity of GC genotype rs7966230 in patients with CHF complicated with venous thrombosis was significantly higher than that of CC genotype(P<0.05),but there was no significant difference in vWF activity among different genotypes of different nationalities(P>0.05).Plasma vWF activity was positively correlated with rs7966230 genotype in patients with CHF complicated with venous thrombosis(r=0.433,P=0.034),but not with nationality(r=-0.017,P=0.913).Conclusion Plasma vWF activity in patients with CHF complicated with venous thrombosis was correlated with rs7966230 genotype,but not with nationality.