硫酸镁联合拉贝洛尔治疗子痫前期孕妇临床疗效及对肾功能和血清炎症因子的影响

Effect of Magnesium Sulfate Combined with Labetalol Hydrochloride on Renal Function and Serum Inflammatory Factors in Pregnant Women with Preeclampsia

目的:探讨硫酸镁联合盐酸拉贝洛尔治疗子痫前期孕妇的临床疗及对妊娠结局、肾功能和血清炎症因子的影响。方法:选取2020年1月—2021年10月我院收治的子痫前期患者72例,随机分为对照组和观察组,各36例。对照组采用硫酸镁治疗,观察组采用硫酸镁联合盐酸拉贝洛尔治疗,比较两组治疗前后血压情况、生化指标(24 h尿蛋白定量、血清同型半胱氨酸、C反应蛋白)、剖宫产率及并发症发生率。结果:治疗后,两组血压改善情况优于治疗前,且观察组优于对照组,差异有统计学意义(P<0.05);观察组治疗后24 h尿蛋白定量、C反应蛋白、同型半胱氨酸水平低于对照组,差异有统计学意义(P<0.05);观察组剖宫产率低于对照组,差异有统计学意义(P<0.05);观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:硫酸镁联合盐酸拉贝洛尔治疗可有效控制子痫前期患者血压及血清因子水平,降低剖宫产率及并发症发生率。

Objective:To investigate the clinical treatment of magnesium sulfate combined with labetalol hydrochloride for pregnant women with preeclampsia and its effect on pregnancy outcome,renal function and serum inflammatory factors.Methods:A total of 72 patients with preeclampsia admitted to our hospital from January 2020 to October 2021 were randomly divided into control group and observation group,with 36 cases in each group.The control group was treated with magnesium sulfate,and the observation group was treated with magnesium sulfate combined with labetalol hydrochloride.The blood pressure,biochemical indexes(24 h urinary protein,serum homocysteine,C-reactive protein),cesarean section rate and incidence of complications were compared between the two groups before and after treatment.Results:After treatment,the improvement of blood pressure in the two groups was better than that before treatment,and the observation group was better than the control group,the difference was statistically significant(P<0.05);24 h urinary protein,C-reactive protein and homocysteine levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The cesarean section rate of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Magnesium sulfate combined with labetalol hydrochloride can effectively control blood pressure and serum factor levels in patients with preeclampsia,and reduce cesarean section rate and incidence of complications.