不同剂量阿托伐他汀钙治疗缺血性脑卒中患者的效果分析

Analysis of the Effect of Different Doses of Atorvastatin Calcium in the Treatment of Patients with Ischemic Stroke

目的:探讨不同剂量阿托伐他汀钙治疗缺血性脑卒中患者的效果。方法:选择2020年1月—2021年6月在该院进行治疗的80例缺血性脑卒中患者,随机分为两组,每组40例。对照组给予20 mg/d阿托伐他汀钙治疗,研究组给予40 mg/d阿托伐他汀钙治疗,比较两组临床疗效、治疗前后血脂水平(TC、TG、LDL-C)、一氧化氮(NO)、内皮素-1(ET-1)、血管扩张百分率(FMD)水平、不良反应。结果:研究组治疗总有效率为97.50%,高于对照组的75.00%,差异有统计学意义(P<0.05);研究组TC、TG、LDL-C低于对照组,差异有统计学意义(P<0.05);研究组ET-1水平低于对照组,NO、FMD水平高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:大剂量的阿托伐他汀钙治疗缺血性脑卒中效果较为明显、血脂水平、血管内皮功能得到很大程度改善,安全性高。

Objective:To explore the effect of different doses of atorvastatin calcium in the treatment of patients with ischemic stroke.Methods:A total of 80 patients with ischemic stroke who were treated in this hospital from January 2020 to June 2021 were selected.The patients were randomly divided into two groups,with 40 patients in each group.The control group was treated with 20 mg/d atorvastatin calcium and the study group was treated with 40 mg/d atorvastatin calcium.The clinical efficacy,blood lipid levels(TC,TG,LDL-C)and monoxide levels before and after treatment were compared between the two groups.Nitrogen(NO),endothelin-1(ET-1),percent vasodilation(FMD)levels,adverse reactions.Results:The total effective rate of the study group was 97.50%,which was higher than 75.00%of the control group,and the difference was statistically significant(P<0.05).The levels of TC,TG and LDL-C in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).The level of ET-1 in the study group was lower than that in the control group,and the levels of NO and FMD were higher than those in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Large doses of atorvastatin calcium have obvious effects in the treatment of ischemic stroke,blood lipid levels and vascular endothelial function have been greatly improved,and the safety is high.