白细胞介素-17在子代孤独症谱系障碍中的相关研究进展

Research progress of interleukin-17 in offspring autism spectrum disorder

白细胞介素-17(IL-17)在机体免疫应答以及炎症性反应中起着十分重要的作用。研究发现高水平的IL-17与多种自身免疫性疾病、急慢性神经退行性疾病和精神疾病的发病有关。孤独症谱系障碍(ASD)是一组儿童时期较为常见的神经发育障碍性疾病, 近期的临床及实验研究将妊娠期母体免疫激活(MIA)与子代患ASD风险联系起来。研究发现, IL-17水平在MIA诱导的子代ASD中明显升高, 是MIA导致子代小鼠神经发育异常的关键因素。现通过阐述IL-17与子代ASD间的最新研究进展, 为ASD的预防和治疗提供新的思路。

Interleukin-17(IL-17)plays an important role in the body′s immune response and inflammatory response.High levels of IL-17 are associated with a variety of autoimmune diseases,acute and chronic neurodegenerative diseases,and psychiatric disorders.Autism spectrum disorder(ASD)is a group of common neurodevelopmental disorders in childhood.Recent clinical and experimental studies have linked maternal immune activation(MIA)during pregnancy to the risk of ASD in offspring.Significantly increased IL-17 level is found in MIA-induced progeny ASD,which is the key factor leading to neurodevelopmental abnormalities in progeny mice.This article reviews the latest research progress on the relationship between IL-17 and progeny ASD,and provides new ideas for the prevention and treatment of ASD.