大学生血尿酸增高与糖脂代谢的相关性

Correlation between higher serum uric acid and glycolipid metabolism in college students

目的探究大学生血尿酸增高流行病学特征及其与糖脂代谢相关性,为高校学生保健相关干预与教育提供参考。方法采用分层整群随机抽样法于2020年9月—2021年11月选取台州市2所高校989名大学生进行调查。分别采用尿素酶免疫法、酶联免疫吸附法检测受检者血尿酸(SUA)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、总胆固醇(TC)、三酰甘油(TG)水平。结果大学生血尿酸增高组腰围、体质量指数、收缩压、舒张压均高于正常组(t值分别为21.72,5.74,5.45,12.23,P值均<0.05);血尿酸增高组SUA、FPG、TG、2 hPG、LDL、TC均高于正常组,HDL低于正常组(t值分别为29.40,23.97,10.24,7.62,34.91,8.27,-8.15,P值均<0.05)。Pearson相关分析发现,SUA水平与FPG、TG、2 hPG、LDL、TC水平均呈正相关,与HDL呈负相关(r值分别为0.63,0.72,0.69,0.16,0.81,-0.52,P值均<0.01)。将糖脂代谢指标纳入二分类多因素Logistic回归模型,结果显示,FPG、TG、LDL、TC与血尿酸增高发生均呈正相关,HDL与血尿酸增高发生呈负相关(P值均<0.05)。结论男性、饮酒、抽烟、血压上升易发生血尿酸增高,血尿酸增高的发生与糖脂代谢有相关性。

Objective To explore the epidemiological characteristics of elevated serum uric acid in college students and its association with glycolipid metabolism,providing reference for health care intervention and education of college students.Methods From September 2020 to November 2021,a retrospective study was conducted among 989 college students in Taizhou area by stratified cluster random sampling method,and a questionnaire was issued to all college students.Serum uric acid(SUA),high density lipoprotein(HDL),low density lipoprotein(LDL),fasting plasma glucose(FPG),2 h postprandial blood glucose(2 hPG),total cholesterol(TC),triglyceride(TG)levels were detected by urease immunoassay and enzyme-linked immunosorbent assay.Results Waist circumference,body mass index,systolic blood pressure and diastolic blood pressure in higher serum uric acid group were higher than those in normal group(t=21.72,5.74,5.45,12.23,P<0.05).The SUA,FPG,TG,2 hPG,LDL and TC in serum uric acid increased group were higher than those in normal group,while HDL was lower than those in normal group(t=13.85,23.97,10.24,7.62,34.91,8.27,-8.15,P<0.05).Pearson correlation analysis showed that the levels of FPG,TG,2 hPG,LDL and TC were positively correlated with SUA levels(r=0.63,0.72,0.69,0.16,0.81,P<0.01).HDL was negatively correlated with SUA level(r=-0.52,P<0.01).The glucolipid metabolism indexes were included into the binary Logistic regression model analysis,and the results showed that FPG,TG,LDL and TC were positively correlated with higher serum uric acid.HDL was negatively correlated with the incidence of higher serum uric acid(P<0.05).Conclusion Male sex,alcohol consumption,smoking,and elevated blood pressure can contribute to higher serum uric acid,which has been found to be associated with glycolipid metabolism.