血小板添加剂的最新研究进展及其评估

Platelet additive solutions:a review of the latest developments and their evaluation

输注血浆保存的血小板可能引起过敏、发热和循环超负荷等输血不良反应。因此,长期以来血液服务机构一直致力于血小板添加剂(PAS)的研究。如何通过优化血小板代谢和改变血小板储存温度来提高血小板体外保存的质和量是实验研究的热点。国外在这一领域的临床实践开展比较早,目前已经积累了大量临床资料和关于使用添加了PAS血液制品的经济效益分析。该研究就PAS如何解决这些问题的相关研究进展和国外的实践经验作一总结。

Transfusion of platelets with plasma may induce adverse transfusion reaction,like hypersusceptibility,fever and circulatory overload.Therefore,blood service always focuses on the research of platelet additive solution(PAS).The hotspots in this field include improving the metabolism of platelets and changing the temperature of platelet storage to advance the quality and quantity of the platelets in vitro.Foreign countries have done clinical practice in this field relatively early,and collected a large number of clinical outcomes and cost effectiveness on the use of PAS.The aim of this review is to summarize some recent researches on platelet storage issue and relevant experience in foreign countries.