D2-40、生长抑素受体2在藏族人群脑膜瘤中的表达情况及诊断意义

Expression and Diagnostic Significance of D2-40 and Somatostatin Receptors 2 in Meningiomas in Tibetan Population

目的:探讨免疫组织化学染色D2-40及生长抑素受体2(Somatostatin Receptors 2,SSTR2)在藏族人群脑膜瘤中的表达情况及诊断和鉴别诊断意义。方法:收集2019—2020年期间西藏自治区人民医院病理科存档的34例全部脑膜瘤病例的患者临床及病理资料。34例病例均经SSTR2、D2-40、AR、ER、PR、EMA、GFAP、S-100、Ki-67等免疫组织化学染色。收集同时期病理科存档的15例神经系统间叶源性肿瘤病例(神经鞘瘤12例,孤立性纤维性肿瘤3例)作为对照组,对照组全部病例均经SSTR2、D2-40免疫组化染色。结果:34例脑膜瘤病例中32例为颅内占位,2例为椎管内占位。显微镜下,31例为WHO I级脑膜瘤,3例为WHO II级脑膜瘤。免疫组织化学染色结果显示脑膜瘤组31例(31/34,91.2%)D2-40阳性表达,32例(32/34,94.1%)SSTR2阳性表达;对照组11例(11/15,73.3%)D2-40阳性表达,15例SSTR2均为阴性。SSTR2在脑膜瘤组和对照组的表达差异有统计学意义(P<0.05)。结论:SSTR2和D2-40在超过90%的藏族人群脑膜瘤病例中阳性表达,有助于脑膜瘤的辅助诊断。SSTR2有助于脑膜瘤与其他神经系统间叶源性肿瘤的鉴别诊断。

Objective To investigate the expression of immunohistochemistrical antibody of D2-40 and somatostatin receptors 2(SSTR2)in meningiomas in Tibetan population and their diagnostic and differential diagnosis significance.MethodsA total of 34 cases of meningiomas archived in the Department of Pathology of Tibet Autonomous Region People′s Hospital from 2019 to 2020 were retrospectively analyzed, and the clinical and pathological data were collected. All 34 cases were immunohistochemistrical stained by SSTR2, D2-40, AR, ER,PR, EMA, GFAP, S-100, Ki-67, etc. 15 cases of mesenchymal tumors of the nervous system(12 cases of schwannomas, 3 cases of solitary fibrous tumours) archived in the pathology department during the same period were collected as a control group, and all cases of control group were stained by SSTR2 and D2-40.Results There were 34 cases of meningiomas, 32 cases were located in intracranial and 2 cases were intraspinal space occupying. Microscopically,there were 31 cases of WHO grade I meningioma, and 3 cases of WHO grade II meningioma. Immunohistochemistrically, D2-40 was positive in 31 meningioma cases(31/34, 91.2%), and SSTR2 was positive in 32 cases(32/34, 94.1%). In control group, D2-40 was positive in 11 cases(11/15,73.3%),and SSTR2 was negative in all cases. There was significant difference in SSTR2 expression between meningioma group and control group(P<0.05).ConclusionImmunohistochemical staining of D2-40 and SSTR2 are positive in more than 90% of meningiomas in Tibetan population, and can help auxiliary diagnosis of meningiomas.Among them, SSTR-2 has differential diagnosis value and can be differentiated from other mesenchymal tumours of the nervous system.