肥胖诱发结肠癌机制的研究进展

Progress of the mechanism in Obesity-induced colon cancer

肥胖是一种慢性代谢性疾病,脂肪细胞通过表达促炎细胞因子(如TNF-α、IL-1和IL-6)、活化免疫细胞以及激活炎症通路,进而促进机体炎症信号激活。流行病学研究表明,肥胖诱发的慢性低度炎症会显著增加结肠癌的发病风险,这是因为脂肪细胞还可通过调控瘦素、脂联素以及胰岛素/IGF-1的表达诱发癌变。本文简要概述了肥胖诱发结肠癌机制的最新证据,以期为结肠癌的机制研究和临床诊治提供思路。

Obesity is a kind of chronic metabolic disease.Adipocytes promotes the activation of inflammatory signals in the body through expressing proinflammatory cytokines(such as TNF-α,IL-1 and IL-6),and activating immune cells and inflammatory pathways.Epidemiological studies have shown that chronic low-grade inflammation induced by obesity could significantly increase the risk of colon cancer,because adipocytes could also induce cancerization by regulating the expressions of leptin,adiponectin and insulin/IGF-1.This article briefly summarizes the latest evidence on the mechanism of obesity-induced colon cancer,so as to provide new ideas for the mechanism research and clinical diagnosis and treatment of colon cancer.