奥沙西泮联合阿米替林治疗抑郁症的临床研究

Clinical study of oxazepam combined with amitriptyline in treatment of depression

目的探讨奥沙西泮联合阿米替林治疗抑郁症的临床疗效。方法选取2020年12月—2021年12月芜湖市第四人民医院精神科诊疗的100例伴躯体症状抑郁症患者,按照随机数字表法分为对照组和治疗组,每组各50例。对照组患者口服盐酸阿米替林片,25 mg/次,3次/d。治疗组在对照组的基础上口服奥沙西泮片,30 mg/次,3次/d。两组患者持续治疗8周。观察两组的临床疗效和症状改善时间。比较两组治疗前后汉密尔顿抑郁量表(HAMD)评分、症状自评量表(SCL-90)评分及血清白细胞介素6(IL-6)、白细胞介素2(IL-2)、肿瘤坏死因子(TNF-α)、白细胞介素1β(IL-1β)水平的变化情况。结果治疗后,治疗组总有效率是98.0%,显著高于对照组的80.0%(P<0.05)。经治疗,治疗组出现入睡困难、食欲下降、疲乏无力、情绪烦躁等症状改善时间均显著短于对照组(P<0.05)。治疗后,两组HAMD评分、SCL-90评分均较治疗前显著降低(P<0.05);治疗后,治疗组HAMD评分、SCL-90评分均低于对照组(P<0.05)。治疗后,两组血清IL-6、IL-2、TNF-α、IL-1β水平均较治疗前显著降低(P<0.05);治疗组血清学指标水平低于对照组(P<0.05)。结论奥沙西泮联合阿米替林治疗伴躯体症状抑郁症效果确切,可明显改善症状,降低炎性细胞因子,值得临床推广。

Objective To investigate the efficacy of oxazepam combined with amitriptyline in treatment of depression.Methods A total of 100 cases of depression with somatic symptoms treated in the Department of Psychiatry of The Fourth People’s Hospital of Wuhu from December 2020 to December 2021 were selected and divided into control group and treatment group according to random number table method,with 50 cases in each group.Patients in the control group were po administered with Amitriptyline Hydrochloride Tablets,25 mg/time,three times daily.Patients in the treatment group were po administered with Oxazepam Tablets on the basis of the control group,30 mg/time,three times daily.Patients in two groups were treated for 8 weeks.After treatment,the clinical efficacy and symptom improvement time of the two groups were observed.The changes of Hamilton Depression Scale(HAMD)score,SCL-90 score,interleukin 6(IL-6),interleukin 2(IL-2),tumor necrosis factor(TNF-α)and interleukin 1β(IL-1β)levels were compared between the two groups before and after treatment.Results After treatment,the total effective rate of treatment group was 98.0%,significantly higher than that of control group 80.0%(P<0.05).After treatment,the improvement time of symptoms such as difficulty falling asleep,decreased appetite,fatigue and weakness,and emotional irritability in the treatment group was significantly shorter than that in the control group(P<0.05).After treatment,HAMD score and SCL-90 score in two groups were significantly decreased compared with before treatment(P<0.05).After treatment,HAMD score and SCL-90 score were lower than those of control group(P<0.05).After treatment,the levels of IL-6,IL-2,TNF-αand IL-1βin two groups were significantly decreased compared with before treatment(P<0.05).The level of serological indexes in treatment group was lower than that in control group(P<0.05).Conclusion Oxazepam combined with amitriptyline has definite effect in treatment of depression,and can obviously improve symptoms,reduce inflammatory cytokines,which is worthy of clinical promotion.