复方风湿宁片联合塞来昔布治疗早期膝骨关节炎的临床研究

Clinical study on Compound Fengshining Tablets combined with celecoxib in treatment of early knee osteoarthritis

目的探讨复方风湿宁片联合塞来昔布胶囊治疗早期膝骨关节炎的临床疗效。方法选取2019年10月—2020年8月在鄂州市中心医院治疗的78例早期膝骨关节炎患者,将患者随机分为对照组和治疗组,每组各39例。对照组口服塞来昔布胶囊,200 mg/次,1次/d;治疗组在对照组基础上口服复方风湿宁片,5片/次,4次/d。两组患者均连续治疗1个月。观察两组临床疗效,比较两组膝关节液中炎症因子水平、膝关节功能、疼痛程度和不良反应。结果治疗后,治疗组总有效率为92.31%,高于对照组总有效率74.36%,组间比较有显著差异(P<0.05)。治疗后,两组膝关节液肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、基质金属蛋白酶-3(MMP-3)水平均显著降低(P<0.05),且治疗组膝关节液TNF-α、IL-1β、MMP-3水平低于对照组(P<0.05)。治疗后,两组Lysholm评分均升高,视觉模拟评分法(VAS)评分均降低(P<0.05),且治疗组Lysholm评分高于对照组,VAS评分低于对照组(P<0.05)。治疗后,治疗组不良反应发生率低于对照组(P<0.05)。结论复方风湿宁片联合塞来昔布胶囊治疗早期膝骨关节炎具有较好的临床疗效,能够促进膝关节修复,减轻患者疼痛程度,可有效降低患者的膝关节液炎性因子水平,抑制炎症反应,安全性较好。

Objective To investigate the effect of Compound Fengshining Tablets combined with Celecoxib Capsules in treatment of early knee osteoarthritis.Methods Patients(78 cases)with early knee osteoarthritis in Ezhou Central Hospital from October 2019 to August 2020 were randomly divided into control and treatment groups,and each group had 39 cases.Patients in the control group were po administered with Celecoxib Capsules,200 mg/time,once daily.Patients in the treatment group were po administered with Compound Fengshining Tablets on the basis of the control group,5 tablets/time,four times daily.Patients in two groups were treated for 1 month.After treatment,the clinical efficacies were evaluated,and the level of inflammatory factors in knee joint fluid,the knee function,degree of pain,and adverse reactions in two groups were compared.Results After treatment,the total effective rate of the treatment group was 92.31%,which was higher than 74.36%of the control group,and there was significant difference between two groups(P<0.05).After treatment,the levels of TNF-α,IL-1β,and MMP-3 in knee joint fluid of two groups were significantly decreased(P<0.05),and the levels of TNF-α,IL-1β,and MMP-3 in knee joint fluid of the treatment group were lower than those of the control group(P<0.05).After treatment,the Lysholm score in two groups were increased,but the VAS score in two groups were decreased(P<0.05).And the Lysholm score in the treatment group was higher than that in the control group,but the VAS score in the treatment group was lower than that in the control group(P<0.05).After treatment,the incidence of adverse reactions in the treatment group was lower than that in the control group(P<0.05).Conclusion Compound Fengshining Tablets combined with Celecoxib Capsules has clinical curative effect in treatment of early knee osteoarthritis,can promote the repair of knee joint,reduce the degree of pain,effectively reduce the level of inflammatory factors in knee joint fluid,and inhibit inflammatory reaction,with good safety.