治疗早泄的表面麻醉剂的研究进展

Research progress on topical anesthetics for premature ejaculation

早泄是在男性群体中普遍存在的疾病,其治疗药物主要分为局部外用药物和口服药物。表面麻醉剂具有良好的疗效、最小的全身副作用并且可以“按需”使用,是治疗早泄的首选药物之一。局部共晶混合物利丙双卡因喷雾剂是用于早泄治疗的审批通过药物。表面麻醉剂治疗早泄的标签外使用药物包括利丙双卡因乳膏、Stud-100喷雾剂、Promescent喷雾剂和SS霜。通过表面麻醉剂联合5型磷酸二酯酶抑制剂、5-羟色胺再摄取抑制剂、中药制剂还可以提高临床疗效。总结了治疗早泄的表面麻醉剂的研究进展,为临床用药和新药研发提供思路。

Premature ejaculation is a common disease in men,and its treatment drugs are mainly divided into topical drugs and oral drugs.Topical anesthetics have good efficacy,minimal systemic side effects,and can be used"on demand",and are one of the drugs of choice for treatment of premature ejaculation.Topical eutectic mixture Lidocaine and Prilocaine Spray is an approved medication for the treatment of premature ejaculation.Off-label topical anaesthetics for premature ejaculation include Lidocaine and Prilocaine Cream,Stud-100 Spray,Promescent Spray,and SS Cream.Topical anesthetics combined with phosphodiesterase type 5 inhibitors,serotonin reuptake inhibitors,and traditional Chinese medicine preparations can also improve clinical efficacy.This paper summarizes the research progress on topical anesthetics for the treatment of premature ejaculation,and provides ideas for clinical drug use and new drug development.