肌酐/体重比值与代谢相关脂肪性肝病的相关性分析

The correlation analysis between creatinine to body weight ratio and metabolic associated fatty liver

目的探讨肌酐/体重(Cr/BW)比值与代谢相关脂肪性肝病(MAFLD)的关系。方法1,050例体检者根据是否患有MAFLD分为MAFLD组(380例)和非MAFLD组(670例),收集并比较两组的性别、体质量指数(BMI)、饮酒史、其他慢性疾病史等一般资料,以及白细胞(WBC)计数、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、Cr/BW等血常规生化检测结果。再根据Cr/BW比值的中位值(男1.123、女1.001)进行分组,低Cr/BW组(524例)和高Cr/BW组(526例),比较两组的一般资料以及血常规生化检测结果。采用Spearman秩相关分析及多因素logistic回归分析Cr/BW与MAFLD的相关性。结果参加调查研究的1,050例体检者中MAFLD的患病率约为36.2%。Spearman秩相关性分析结果显示,Cr/BW比值与MAFLD的患病呈负相关(r=-0.352,P<0.001)。校正性别、年龄、吸烟史、饮酒史、血压、血糖、血脂等混杂因素后,多因素logistic回归分析结果显示Cr/BW比值是MAFLD患病的独立相关因素(OR=0.013,95%CI=1.101~2.284),随着Cr/BW比值的降低,MAFLD的患病风险增加;HDL-C是MAFLD的保护因素(OR=0.210,95%CI=0.098~0.448)。结论Cr/BW比值与MAFLD患病相关,可能反映人体骨骼肌占体重的比例。

Objective To investigate the relationship between creatinine to body weight(Cr/BW)ratio and metabolic associated fatty liver disease(MAFLD).Methods A total of 1,050 physical examination subjects were divided into MAFLD group(380 cases)and non-MAFLD group(670 cases)according to whether they had MAFLD.General data such as gender,body mass index(BMI),drinking history and other chronic disease history,and white blood cells(WBC)count,high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),Cr/BW and other routine biochemical test results were collected and compared between the two groups.Then according to the median value of Cr/BW ratio(male 1.123,female 1.001),they were divided into low Cr/BW group(524 cases)and high Cr/BW group(526 cases),and the general data and blood routine biochemical test results of the two groups were compared.Spearman rank correlation analysis and logistic regression were used to analyze the correlation between Cr/BW and MAFLD.Results The prevalence of MAFLD in 1,050 subjects was 36.2%.Spearman rank correlation analysis showed that Cr/BW ratio was negatively correlated with the incidence of MAFLD(r=-0.352,P<0.001).After adjusting for confounding factors such as gender,age,smoking history,drinking history,blood pressure,blood glucose and blood lipids,multivariate logistic regression analysis showed that Cr/BW ratio was an independent correlation factor of MAFLD(OR=0.013,95%CI=1.101~2.284).With the decrease of Cr/BW ratio,the risk of MAFLD increased,HDL-C was a protective factor for MAFLD(OR=0.210,95%CI=0.098~0.448).Conclusion Cr/BW ratio is associated with MAFLD and may reflect the proportion of skeletal muscle to body weight.