丁苯酞注射液改善血管性认知功能障碍的效果

Effect of butylphthalide injection on improving vascular cognitive impairment

目的 观察丁苯酞注射液改善血管性认知功能障碍(VCI)的临床疗效和安全性。方法 将2017年6月—2020年6月天津市职业病防治院收治的124例VCI患者随机分为治疗组和对照组各62例。对照组患者采用奥拉西坦治疗,治疗组采用丁苯酞治疗。比较两组患者治疗前后的简易精神状态检查(MMSE)评分、日常生活能力(ADL)评分、治疗效果及不良反应发生率。结果 治疗后,两组MMSE和ADL评分均优于治疗前,且治疗组MMSE和ADL评分为(24.8±2.2)和(45.1±6.1)分,均优于对照组的(23.0±2.8)和(41.4±5.2)分,差异均有统计学意义(P<0.05)。治疗组治疗总有效率为79.0%,高于对照组的62.9%,差异有统计学意义(P<0.05)。两组治疗后第7、14天进行血液常规检测,肝、肾功能和心电图指标无明显变化。治疗组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论 丁苯酞注射液能改善VCI患者的认知功能,安全性较高,值得临床应用推广。

Objective To observe the clinical efficacy and safety of butylphthalide injection on improving vascular cognitive impairment(VCI). Methods A total of 124 patients with VCI treated in Tianjin Occupational Diseases Precaution and Therapeutic Hospital from June 2017 to June 2020 were randomly divided into treatment group and control group, with 62 cases in each group. The patients in the control group were treated with oxiracetam, and the patients in the treatment group were treated with butylphthalide. Mini mental state examination(MMSE) score, activity of daily living(ADL) score before and after treatment,treatment effect and incidence of adverse reactions were compared between the two groups. Results After treatment, the MMSE and ADL scores of the two groups were better than those before treatment, and the MMSE and ADL scores of the treatment group were(24.8±2.2) and(45.1±6.1) points, which were better than those of the control group with(23.0±2.8) and(41.4±5.2) points, and the differences were statistically significant(P<0.05). The total effective rate of the treatment group was 79.0%, which was higher than 62.9%of the control group, and the difference was statistically significant(P <0.05). Routine blood tests were carried out on the 7th and 14th days after treatment in the two group, and there were no significant changes in liver and kidney functions and ECG indexes. There was no significant difference in the incidence of adverse reactions between the treatment group and the control group(P>0.05). Conclusion Butylphthalein injection could improve the cognitive function of patients with VCI, with high safety, which was worthy of clinical application and promotion.