双歧杆菌三联活菌散对特应性体质毛细支气管炎患儿免疫球蛋白E和白细胞介素17水平的影响

Effect of Bifidobacterium triple viable bacteria powder on immunoglobulin E and interleukin 17 levels in children with atopic bronchiolitis

目的探讨双歧杆菌三联活菌散对特应性体质毛细支气管炎患儿免疫球蛋白E(IgE)和白细胞介素17(IL-17)水平的影响。方法选取84例笔者所在医院于2019年6月至2020年6月所收治的特应性体质毛细支气管炎患儿为研究对象,将其随机分为常规组与三联组,常规组患者行常规治疗,三联组患者于常规组基础上加施双歧杆菌三联活菌散治疗,分别于患儿入院时与治疗2个月后抽取患儿的空腹静脉血行血清IgE和IL-17水平检测,比较了两组患者治疗前后的IgE和IL-17水平及不良反应的发生情况。结果两组患儿治疗前的IgE和IL-17水平比较无统计学意义(P>0.05),治疗后均下降,且三联组患儿治疗后的IgE和IL-17水平分别为(56.63±9.22)μg/L、(49.58±6.28)μg/L,较常规组的(70.49±11.27)μg/L、(54.76±6.34)μg/L更低,有统计学意义(P<0.05);三联组患儿不反应的发生率为9.52%,与常规组的7.14%比较无统计学意义(P>0.05)。结论双歧杆菌三联活菌散可有效降低特应性体质毛细支气管炎患儿的IgE和IL-17水平,且不易产生不良反应,具较高安全性,值得在临床治疗当中推广应用。

Objective To investigate the effect of Bifidobacterium triple viable bacteria powder on the levels of immunoglobulin E(IgE)and interleukin-17(IL-17)in children with atopic bronchiolitis.Methods Eighty-four children with atopic bronchiolitis admitted to our hospital from June 2019 to June 2020 were randomly divided into routine group and triple group.Patients in routine group received routine treatment,while patients in triple group were treated with Bifidobacterium triple viable powder on the basis of routine group.Serum IgE and IL-17 levels were detected in the fasting venous blood of children when they were admitted to hospital and 2 months after treatment.IgE and IL were compared between the two groups before and after treatment.Results The levels of IgE and IL-17 in the two groups had no significant difference before treatment(P>0.05),but decreased after treatment.The levels of IgE and IL-17 in the triple group were(56.63±9.22)μg/L and(49.58±6.28)μg/L respectively,which were higher than those in the conventional group(70.49±11.27)The incidence of non-reaction in triple group was 9.52%,which was not statistically significant compared with 7.14%in routine group(P>0.05).Conclusion Bifidobacterium triple viable bacteria powder can effectively reduce the levels of IgE and IL-17 in children with atopic bronchiolitis,and it is not easy to produce adverse reactions.It has high safety and is worthy of popularization and application in clinical treatment.