莫沙必利联合氟哌噻吨美利曲辛对伴焦虑抑郁状态FD患者的胃排空功能、胃肠激素水平及精神状态的影响

The effect of mosapride combined with flupentixol and melitroxine on gastric emptying function,gastrointestinal hormone levels and mental state in patients with FD with anxiety and depression

目的探究莫沙必利联合氟哌噻吨美利曲辛对功能性消化不良(FD)伴焦虑抑郁状态患者的胃排空功能、胃肠激素水平及精神状态的影响。方法选取我科2017年10月至2019年10月期间89例伴焦虑抑郁状态的FD患者,根据随机数字表法分组。对照组44例予以莫沙必利治疗,观察组45例予莫沙必利联合氟哌噻吨美利曲辛治疗,观察两组患者的临床疗效、胃排空功能、胃肠激素水平、精神状态及不良反应。结果治疗后观察组VIP水平、SAS、SDS、胃底气体评分低于对照组,MTL、SP水平、总有效率、胃排空率高于对照组,有统计学意义(P<0.05)。观察组不良反应发生率8.89%高于对照组6.82%,无统计学意义(P>0.05)。结论莫沙必利联合氟哌噻吨美利曲辛对伴焦虑抑郁状态FD患者治疗,可有效降低焦虑抑郁情绪,改善胃肠激素水平和胃肠排空功能,提升临床疗效,药物安全性高。

Objective To explore the effect of mosapride combined with flupentixol and melitrazin on gastric emptying function,gastrointestinal hormone levels and mental status in patients with functional dyspepsia(FD)with anxiety and depression.Methods From October 2017 to October 2019 in our department,89 FD patients with anxiety and depression were selected and grouped according to the random number table method.44 patients in the control group were treated with mosapride,and 45 patients in the observation group were treated with mosapride combined with flupentixol and melitroxine.The clinical efficacy,gastric emptying function,gastrointestinal hormone levels,and spirit of the two groups Status and adverse reactions.Results After treatment,the VIP level,SAS,SDS,and gastric fundus scores of the observation group were lower than those of the control group,and the MTL,SP levels,total effective rate,and gastric emptying rate were higher than those of the control group,with statistical significance(P<0.05).The incidence of adverse reactions in the observation group was 8.89%higher than that in the control group 6.82%,which was not statistically significant(P>0.05).Conclusion Mosapride combined with flupentixol and melitroxine can effectively reduce anxiety and depression in patients with FD with anxiety and depression,improve gastrointestinal hormone levels and gastrointestinal emptying function,improve clinical efficacy and drug safety high.