摘要
目的 通过化学方法合成3类含有咪唑的二酮基哌嗪生物碱(penilloid A、JBIR-74、JBIR75)。方法 以氨基酸衍生物为起始原料,经缩合、脱保护、环化、乙酰化、羟醛缩合和去乙酰化等反应合成目标化合物。结果 合成了6个含有咪唑基的二酮哌嗪类化合物,包括天然产物penilloid A、JBIR-74、JBIR-75。其中penilloid A和JBIR-74为首次合成,为二酮哌嗪类化合物的化学合成方法提供了新的思路和方法。
Objective To synthesize a series of imidazole-containing piperazine-2, 5-dione alkaloids including Penilloid A, JIR-74 and JIR-75. Methods Amino acid derivatives were used as starting materials, and target compounds were synthesized by condensation, deprotection, cyclization, acetylation, aldol condensation and deacetylation. Results Six diketopiperazine derivatives were synthesized, including marine natural products Penilloid A, JIR-74 and JIR-75. Penilloid A and JIR-74 were synthesized for the first time, which provided a novel method for the chemical synthesis of diketopiperazine derivatives.
作者
吴广鑫
张帅
刘万冬
万升标
WU Guang-xin;ZHANG Shuai;LIU Wan-dong;WAN Sheng-biao(Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China;Laboratory for Marine Drugs and Bioproducts of Qingdao Pilot National Laboratory for Marine Science and Technology,Qingdao 266237,China)
出处
《中国海洋药物》
CAS
CSCD
2022年第2期49-54,共6页
Chinese Journal of Marine Drugs
基金
国家自然科学基金项目(81973170)资助。
关键词
二酮基哌嗪
海洋天然产物
化学合成
diketopiperazine
marine natural products
chemical synthesis