NKx 2.5基因的生物学特征及在心脏发育中作用机制的研究进展

Biological characteristics of NKx 2.5 and mechanism of its roles in cardiac development

NKx 2.5基因是目前发现最早的与心脏发育和成熟相关的转录因子,会影响胚胎心脏发育异常,最终可能导致异常的心脏结构和传导功能受阻,甚至死亡。本文综述了NKx 2.5基因的生物学特征及其在心脏发育中的作用机制,NKx 2.5基因在心脏发育过程中与其他转录因子发挥协同作用,共同促进心肌细胞的发育。早期进行NKx 2.5基因检测将有助于筛查遗传性先天性心脏病,预防心动过缓或过速导致的心源性猝死。

NK2 homeobox 5(NKx 2.5)is an earliest transcription factor related to the development and maturation of the heart,which may affect the abnormal development of the embryonic heart,and ultimately lead to the abnormal cardiac structure and conduction function,or even death.In this article,we review the biological characteristics of NKx 2.5 and its mechanism of action in cardiac development,and introduce the newly discovered mutations in patients in recent years.The gene acts synergistically with other transcription factors during heart development to promote the development of precursor cardiomyocytes.Early detection of the gene will help to screen hereditary congenital heart disease and prevent sudden cardiac death caused by bradycardia or tachycardia.