前列腺癌中雄激素受体信号通路与其他信号通路的相互作用

Interactions between androgen receptor and other molecular pathways in prostate cancer

前列腺癌(PCa)的发病率逐年上升,雄激素受体(AR)被认为是PCa生长和进展的主要因素,雄激素剥夺治疗(ADT)是激素敏感性前列腺癌治疗的基石,但大多数患者最终会发展成为去势抵抗性前列腺癌(CRPC)。近年来不断有研究发现在PCa中存在多种信号通路,协同AR通路促进PCa发生和进展,如PTEN/PI3K/AKT/mTOR通路、WNT通路、神经内分泌模式、DNA修复途径、TMPRSS2/ETS融合、细胞周期途径、免疫系统异常、TGF-β通路。在此综述中,我们讨论了在PCa中AR信号与其他信号通路之间的相互作用。

The incidence of prostate cancer(PCa)is rising year by year,and the androgen receptor(AR)is thought to be the main factor in the growth and progress of the disease.Androgen deprivation therapy(ADT)is the foundation of the treatment of hormone-sensitive prostate cancer,but most patients eventually develop into castration-resistant prostate cancer(CRPC).In recent years,there have been various signaling pathways to promote the occurrence and progress of prostate cancer,such as the PTEN/PI3K/AKT/mTOR pathway,WNT pathway,the neuroendocrine model,TMPRSS2/ETS fusion,the cellular cycle pathway,abnormal immune system and TGF-βpathway.In this review,we discussed the interaction between AR pathway and other signaling pathways in prostate cancer.