胆固醇代谢在肝细胞癌发生发展中的作用研究进展

Research progress of cholesterol metabolism disorder in hepatocellular carcinoma

肝细胞癌(HCC)是常见的恶性实体瘤,其发病率高,预后差。尽管病毒性肝炎仍是HCC的最主要病因,近年来随着生活水平的提高和膳食习惯的改变,非酒精性脂肪性肝病正成为HCC不可忽视的病因。新近研究表明,胆固醇代谢紊乱在HCC的发生、发展中扮演着重要的角色。采用各种方法干预胆固醇代谢紊乱,能够有效的预防和治疗HCC。本文通过对近年相关研究进行文献回顾,就胆固醇代谢紊乱在HCC的发生发展中的作用研究进展进行综述。

Hepatocellular carcinoma(HCC)is a common malignant solid tumor with high incidence rate and poor prognosis.Although viral hepatitis is still the main cause of HCC,in recent years,with the improvement of living standards and the change of dietary habits,non-alcoholic fatty liver disease is becoming an important cause of HCC.Recent studies have shown that cholesterol metabolism disorder plays an important role in the occurrence and development of HCC.Using various methods to intervene cholesterol metabolism disorder can effectively prevent and treat HCC.This paper reviews the literature on the role of cholesterol metabolism disorder in the occurrence and development of HCC.