铁死亡在肾结石形成中的研究进展

Research progress of ferroptosis in renal stone formation

肾结石的发生是炎症、脂质代谢紊乱、氧化应激、细胞自噬等一系列病理反应导致的结果。越来越多的研究结果显示铁死亡在肾结石的发病中发挥着至关重要的作用,抑制铁死亡可有效抑制肾结石的产生。草酸钙诱导的自噬和铁死亡降低了细胞抗氧化的能力,导致脂质过氧化增强和肾小管上皮细胞损伤,最终引起肾脏晶体的形成和肾结石的发生。

The occurrence of kidney stones is the result of a series of pathological reactions such as inflammation,lipid metabolism disorder,oxidative stress,and autophagy.More and more studies have found that ferroptosis plays a crucial role in the pathogenesis of nephrolithiasis,and inhibiting ferroptosis will effectively inhibit the production of nephrolithiasis.Calcium oxalate-induced autophagy and ferroptosis reduce cellular antioxidant capacity,leading to enhanced lipid peroxidation and the damage of tubular epithelial cell,which ultimately leads to the formation of renal crystals and the occurrence of renal stones.We hope that this paper can provide new directions for the related research and treatment of kidney stones in the future.